Epidemiology of persistent proteinuria in type II diabetes mellitus. Population-based study in Rochester, Minnesota

D. J. Ballard, L. L. Humphrey, L. J. Melton, P. P. Frohnert, C. P. Chu, W. M. O'Fallon, P. J. Palumbo

Research output: Contribution to journalArticle

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Abstract

Clinical risk factors for nephropathy were assessed in a population-based study of Rochester, Minnesota, residents with diabetes mellitus initially diagnosed between 1945 and 1969 (incidence cohort). The 1031 Rochester residents with non-insulin-dependent diabetes mellitus (NIDDM) were followed through their complete medical records in the community to 1 January 1982. The prevalence of persistent proteinuria was 8.2% at the diagnosis of NIDDM. Among those initially free of persistent proteinuria, the subsequent incidence was 15.3/1000 peron-yr. Twenty years after the diagnosis of diabetes, the cumulative incidence of persistent proteinuria was 24.6%. A proportional hazards model identified the following risk factors for persistent proteinuria in NIDDM: elevated initial fasting blood glucose (P < .01); older age at onset of diabetes (P < .01); male gender (P = .05); and presence of macrovascular disease (P = .05), diabetic retinopathy (P = .05), or glycosuria (P = .07) at the diagnosis of diabetes. Seperate analyses controlling for attained age indicated no association between duration of NIDDM and the incidence of persistent proteinuria. Stratified analysis of the two most significant risk factors (fasting blood glucose and age) indicated that hyperglycemia was a stronger risk factor for proteinuria in younger diabetic subjects, perhaps because of a competing risk of death in the elderly diabetic patient. In contrast to a recently described decreasing secular trend of proteinuria in Danish insulin-dependent diabetes mellitus patients, there was no decrease over the past 40 yr in proteinuria risk in this NIDDM incidence cohort.

Original languageEnglish (US)
Pages (from-to)405-412
Number of pages8
JournalDiabetes
Volume37
Issue number4
StatePublished - 1988

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Proteinuria
Type 2 Diabetes Mellitus
Epidemiology
Population
Incidence
Blood Glucose
Fasting
Glycosuria
Diabetic Retinopathy
Type 1 Diabetes Mellitus
Age of Onset
Proportional Hazards Models
Hyperglycemia
Medical Records
Diabetes Mellitus

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Ballard, D. J., Humphrey, L. L., Melton, L. J., Frohnert, P. P., Chu, C. P., O'Fallon, W. M., & Palumbo, P. J. (1988). Epidemiology of persistent proteinuria in type II diabetes mellitus. Population-based study in Rochester, Minnesota. Diabetes, 37(4), 405-412.

Epidemiology of persistent proteinuria in type II diabetes mellitus. Population-based study in Rochester, Minnesota. / Ballard, D. J.; Humphrey, L. L.; Melton, L. J.; Frohnert, P. P.; Chu, C. P.; O'Fallon, W. M.; Palumbo, P. J.

In: Diabetes, Vol. 37, No. 4, 1988, p. 405-412.

Research output: Contribution to journalArticle

Ballard, DJ, Humphrey, LL, Melton, LJ, Frohnert, PP, Chu, CP, O'Fallon, WM & Palumbo, PJ 1988, 'Epidemiology of persistent proteinuria in type II diabetes mellitus. Population-based study in Rochester, Minnesota', Diabetes, vol. 37, no. 4, pp. 405-412.
Ballard DJ, Humphrey LL, Melton LJ, Frohnert PP, Chu CP, O'Fallon WM et al. Epidemiology of persistent proteinuria in type II diabetes mellitus. Population-based study in Rochester, Minnesota. Diabetes. 1988;37(4):405-412.
Ballard, D. J. ; Humphrey, L. L. ; Melton, L. J. ; Frohnert, P. P. ; Chu, C. P. ; O'Fallon, W. M. ; Palumbo, P. J. / Epidemiology of persistent proteinuria in type II diabetes mellitus. Population-based study in Rochester, Minnesota. In: Diabetes. 1988 ; Vol. 37, No. 4. pp. 405-412.
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