Epidemiology of lung cancer prognosis: Quantity and quality of life

Research output: Chapter in Book/Report/Conference proceedingChapter

67 Scopus citations

Abstract

Primary lung cancer is very heterogeneous in its clinical presentation, histopathology, and treatment response; and like other diseases, the prognosis consists of two essential facets: survival and quality of life (QOL). Lung cancer survival is mostly determined by disease stage and treatment modality, and the 5-Year survival rate has been in a plateau of 15% for three decades. QOL is focused on life aspects that are affected by health conditions and medical interventions; the balance of physical functioning and suffering from treatment side effects has long been a concern of care providers as well as patients. Obviously needed are easily measurable biologic markers to stratify patients before treatment for optimal results in survival and QOL and to monitor treatment responses and toxicities. Targeted therapies toward the mechanisms of tumor development, growth, and metastasis are promising and actively translated into clinical practice. Long-term lung cancer (LTLC) survivors are people who are alive 5 Years after the diagnosis. Knowledge about the health and QOL in LTLC survivors is limited because outcome research in lung cancer has been focused mainly on short-term survival. The independent or combined effects of lung cancer treatment, aging, smoking and drinking, comorbid conditions, and psychosocial factors likely cause late effects, including organ malfunction, chronic fatigue, pain, or premature death among lung cancer survivors. New knowledge to be gained should help lung cancer survivors, their healthcare providers, and their caregivers by providing evidence for establishing clinical recommendations to enhance their long-term survival and health-related QOL.

Original languageEnglish (US)
Title of host publicationCancer Epidemiology
Subtitle of host publicationVolume I: Host Susceptibility Factors
EditorsMukesh Verma
Pages469-486
Number of pages18
DOIs
StatePublished - Feb 23 2009

Publication series

NameMethods in Molecular Biology
Volume471
ISSN (Print)1064-3745

Keywords

  • Chemotherapy
  • Gene expression profiling
  • Non-small cell lung cancer
  • Pharmacogenomics
  • Quality of life
  • Radiation therapy
  • Small cell lung cancer
  • Survival
  • Toxicity

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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  • Cite this

    Yang, P. (2009). Epidemiology of lung cancer prognosis: Quantity and quality of life. In M. Verma (Ed.), Cancer Epidemiology: Volume I: Host Susceptibility Factors (pp. 469-486). (Methods in Molecular Biology; Vol. 471). https://doi.org/10.1007/978-1-59745-416-2_24