Epidemiology of herpes zoster in children and adolescents

A population-based study

H. A. Guess, D. D. Broughton, L. J. Melton, L. T. Kurland

Research output: Contribution to journalArticle

194 Citations (Scopus)

Abstract

Medical records were reviewed for all 173 cases of herpes zoster diagnosed among residents of Rochester, Minnesota, less than 20 years of age during the period 1960 through 1981. The incidence of zoster increased with age from 20 cases per 100,000 person-years in those residents less than five years of age to 63 cases per 100,000 person-years in those aged 15 to 19. Morbidity was less than has been described in adults, as only two patients required hospitalization and no postherpetic neuralgia or other late complications were diagnosed. The single case of subsequent cancer found in 1,288 person-years of follow-up was not significantly different from the number expected based on cancer incidence in the general Rochester population. The incidence of childhood zoster in patients with acute lymphocytic leukemia was 122 times higher than in children without an underlying malignancy. Chickenpox in the first year of life was found to be a risk factor for childhood zoster, with a relative risk between 2.8 and 20.9. Neither chickenpox in the second year of life nor recent vaccinations were found to be risk factors for childhood zoster.

Original languageEnglish (US)
Pages (from-to)512-517
Number of pages6
JournalPediatrics
Volume76
Issue number4
StatePublished - 1985
Externally publishedYes

Fingerprint

Herpes Zoster
Epidemiology
Chickenpox
Population
Incidence
Postherpetic Neuralgia
Neoplasms
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Medical Records
Vaccination
Hospitalization
Morbidity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Guess, H. A., Broughton, D. D., Melton, L. J., & Kurland, L. T. (1985). Epidemiology of herpes zoster in children and adolescents: A population-based study. Pediatrics, 76(4), 512-517.

Epidemiology of herpes zoster in children and adolescents : A population-based study. / Guess, H. A.; Broughton, D. D.; Melton, L. J.; Kurland, L. T.

In: Pediatrics, Vol. 76, No. 4, 1985, p. 512-517.

Research output: Contribution to journalArticle

Guess, HA, Broughton, DD, Melton, LJ & Kurland, LT 1985, 'Epidemiology of herpes zoster in children and adolescents: A population-based study', Pediatrics, vol. 76, no. 4, pp. 512-517.
Guess HA, Broughton DD, Melton LJ, Kurland LT. Epidemiology of herpes zoster in children and adolescents: A population-based study. Pediatrics. 1985;76(4):512-517.
Guess, H. A. ; Broughton, D. D. ; Melton, L. J. ; Kurland, L. T. / Epidemiology of herpes zoster in children and adolescents : A population-based study. In: Pediatrics. 1985 ; Vol. 76, No. 4. pp. 512-517.
@article{416f89d9be784f97b0850c0cf65e24a8,
title = "Epidemiology of herpes zoster in children and adolescents: A population-based study",
abstract = "Medical records were reviewed for all 173 cases of herpes zoster diagnosed among residents of Rochester, Minnesota, less than 20 years of age during the period 1960 through 1981. The incidence of zoster increased with age from 20 cases per 100,000 person-years in those residents less than five years of age to 63 cases per 100,000 person-years in those aged 15 to 19. Morbidity was less than has been described in adults, as only two patients required hospitalization and no postherpetic neuralgia or other late complications were diagnosed. The single case of subsequent cancer found in 1,288 person-years of follow-up was not significantly different from the number expected based on cancer incidence in the general Rochester population. The incidence of childhood zoster in patients with acute lymphocytic leukemia was 122 times higher than in children without an underlying malignancy. Chickenpox in the first year of life was found to be a risk factor for childhood zoster, with a relative risk between 2.8 and 20.9. Neither chickenpox in the second year of life nor recent vaccinations were found to be risk factors for childhood zoster.",
author = "Guess, {H. A.} and Broughton, {D. D.} and Melton, {L. J.} and Kurland, {L. T.}",
year = "1985",
language = "English (US)",
volume = "76",
pages = "512--517",
journal = "Pediatrics",
issn = "0031-4005",
publisher = "American Academy of Pediatrics",
number = "4",

}

TY - JOUR

T1 - Epidemiology of herpes zoster in children and adolescents

T2 - A population-based study

AU - Guess, H. A.

AU - Broughton, D. D.

AU - Melton, L. J.

AU - Kurland, L. T.

PY - 1985

Y1 - 1985

N2 - Medical records were reviewed for all 173 cases of herpes zoster diagnosed among residents of Rochester, Minnesota, less than 20 years of age during the period 1960 through 1981. The incidence of zoster increased with age from 20 cases per 100,000 person-years in those residents less than five years of age to 63 cases per 100,000 person-years in those aged 15 to 19. Morbidity was less than has been described in adults, as only two patients required hospitalization and no postherpetic neuralgia or other late complications were diagnosed. The single case of subsequent cancer found in 1,288 person-years of follow-up was not significantly different from the number expected based on cancer incidence in the general Rochester population. The incidence of childhood zoster in patients with acute lymphocytic leukemia was 122 times higher than in children without an underlying malignancy. Chickenpox in the first year of life was found to be a risk factor for childhood zoster, with a relative risk between 2.8 and 20.9. Neither chickenpox in the second year of life nor recent vaccinations were found to be risk factors for childhood zoster.

AB - Medical records were reviewed for all 173 cases of herpes zoster diagnosed among residents of Rochester, Minnesota, less than 20 years of age during the period 1960 through 1981. The incidence of zoster increased with age from 20 cases per 100,000 person-years in those residents less than five years of age to 63 cases per 100,000 person-years in those aged 15 to 19. Morbidity was less than has been described in adults, as only two patients required hospitalization and no postherpetic neuralgia or other late complications were diagnosed. The single case of subsequent cancer found in 1,288 person-years of follow-up was not significantly different from the number expected based on cancer incidence in the general Rochester population. The incidence of childhood zoster in patients with acute lymphocytic leukemia was 122 times higher than in children without an underlying malignancy. Chickenpox in the first year of life was found to be a risk factor for childhood zoster, with a relative risk between 2.8 and 20.9. Neither chickenpox in the second year of life nor recent vaccinations were found to be risk factors for childhood zoster.

UR - http://www.scopus.com/inward/record.url?scp=0022384558&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022384558&partnerID=8YFLogxK

M3 - Article

VL - 76

SP - 512

EP - 517

JO - Pediatrics

JF - Pediatrics

SN - 0031-4005

IS - 4

ER -