Epidemiology of Eosinophilic Esophagitis Over Three Decades in Olmsted County, Minnesota

Ganapathy A. Prasad, Jeffery A. Alexander, Cathy D. Schleck, Alan R. Zinsmeister, Thomas C. Smyrk, Richard M. Elias, G. Richard Locke, Nicholas J. Talley

Research output: Contribution to journalArticlepeer-review

352 Scopus citations


Background & Aims: Data on secular trends and outcomes of eosinophilic esophagitis (EE) are scarce. We performed a population-based study to assess the epidemiology and outcomes of EE in Olmsted County, Minnesota, over the last 3 decades. Methods: All cases of EE diagnosed between 1976 and 2005 were identified using the Rochester Epidemiology Project resources. Esophageal biopsies with any evidence of esophagitis and/or eosinophilic infiltration were reviewed by a single pathologist. Clinical course (treatment, response, and recurrence) was defined using information collected from medical records and prospectively via a telephone questionnaire. Incidence rates per 100,000 person years were directly adjusted for age and sex to the US 2000 population structure. Results: A total of 78 patients with EE were identified. The incidence of EE increased significantly over the last 3 of the 5-year intervals (from 0.35 [95% confidence interval (CI)], 0-0.87] per 100,000 person-years during 1991-1995 to 9.45 [95% CI, 7.13-11.77] per 100,000 person-years during 2001-2005). The prevalence of EE was 55.0 (95% CI, 42.7-67.2) per 100,000 persons as of January 1, 2006, in Olmsted County, Minnesota. EE was diagnosed more frequently in late summer/fall. The clinical course of patients with EE was characterized by recurrent symptoms (observed in 41% of patients). Conclusions: The prevalence and incidence of EE is higher than previously reported. The incidence of clinically diagnosed EE increased significantly over the last 3 decades, in parallel with endoscopy volume. Seasonal incidence was greatest in late summer and fall. EE also appears to be a recurrent relapsing disease in a substantial proportion of patients.

Original languageEnglish (US)
Pages (from-to)1055-1061
Number of pages7
JournalClinical Gastroenterology and Hepatology
Issue number10
StatePublished - Oct 2009

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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