Epidemiology and natural history of multiple sclerosis: New insights

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

Purpose of review: The cause of multiple sclerosis remains elusive. We review recent epidemiological studies of genetic and environmental factors that influence susceptibility to the disease and its clinical course. Recent findings: Genetic advances strengthen the association of multiple sclerosis with the human leukocyte antigen (HLA)-DRB1 allele and interferon-γ polymorphisms and suggest that apolipoprotein E alleles play an important role. In the environmental realm, nested case-control studies show that prior Epstein-Barr virus exposure is overrepresented in multiple sclerosis. Smoking has been associated with both risk of multiple sclerosis and progressive disease. Vitamin D deficiency might tie together environmental clues with higher multiple sclerosis prevalence rates; dietary vitamin supplementation is also associated with reduced multiple sclerosis risk. Natural history studies demonstrated dissociation between relapses and disease progression, facilitated the ability to distinguish neuromyelitis optica and related syndromes from typical multiple sclerosis, and spawned the exploration of large datasets to model long-term disease activity. Summary: Our understanding of the contributions of specific genetic and environmental factors that contribute to multiple sclerosis has improved. Further refinements will eventually allow powerful longitudinal studies to assess genetic and environmental interactions with implications for prediction of individual disease susceptibility, clinical course, and response to therapy.

Original languageEnglish (US)
Pages (from-to)248-254
Number of pages7
JournalCurrent Opinion in Neurology
Volume19
Issue number3
DOIs
StatePublished - Jun 2006

Fingerprint

Multiple Sclerosis
Epidemiology
Disease Susceptibility
Alleles
Neuromyelitis Optica
Aptitude
Vitamin D Deficiency
Apolipoproteins E
HLA Antigens
Dietary Supplements
Natural History
Human Herpesvirus 4
Vitamins
Interferons
Longitudinal Studies
Disease Progression
Case-Control Studies
Epidemiologic Studies
Smoking
Recurrence

Keywords

  • Environmental factors
  • Epidemiology
  • Genetic factors
  • Longitudinal studies
  • Multiple sclerosis
  • Natural history

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Epidemiology and natural history of multiple sclerosis : New insights. / Kantarci, Orhun H; Wingerchuk, Dean Marko.

In: Current Opinion in Neurology, Vol. 19, No. 3, 06.2006, p. 248-254.

Research output: Contribution to journalArticle

@article{c4c0893ccdd542d8b20d2346d6b7cc73,
title = "Epidemiology and natural history of multiple sclerosis: New insights",
abstract = "Purpose of review: The cause of multiple sclerosis remains elusive. We review recent epidemiological studies of genetic and environmental factors that influence susceptibility to the disease and its clinical course. Recent findings: Genetic advances strengthen the association of multiple sclerosis with the human leukocyte antigen (HLA)-DRB1 allele and interferon-γ polymorphisms and suggest that apolipoprotein E alleles play an important role. In the environmental realm, nested case-control studies show that prior Epstein-Barr virus exposure is overrepresented in multiple sclerosis. Smoking has been associated with both risk of multiple sclerosis and progressive disease. Vitamin D deficiency might tie together environmental clues with higher multiple sclerosis prevalence rates; dietary vitamin supplementation is also associated with reduced multiple sclerosis risk. Natural history studies demonstrated dissociation between relapses and disease progression, facilitated the ability to distinguish neuromyelitis optica and related syndromes from typical multiple sclerosis, and spawned the exploration of large datasets to model long-term disease activity. Summary: Our understanding of the contributions of specific genetic and environmental factors that contribute to multiple sclerosis has improved. Further refinements will eventually allow powerful longitudinal studies to assess genetic and environmental interactions with implications for prediction of individual disease susceptibility, clinical course, and response to therapy.",
keywords = "Environmental factors, Epidemiology, Genetic factors, Longitudinal studies, Multiple sclerosis, Natural history",
author = "Kantarci, {Orhun H} and Wingerchuk, {Dean Marko}",
year = "2006",
month = "6",
doi = "10.1097/01.wco.0000227033.47458.82",
language = "English (US)",
volume = "19",
pages = "248--254",
journal = "Current Opinion in Neurology",
issn = "1350-7540",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Epidemiology and natural history of multiple sclerosis

T2 - New insights

AU - Kantarci, Orhun H

AU - Wingerchuk, Dean Marko

PY - 2006/6

Y1 - 2006/6

N2 - Purpose of review: The cause of multiple sclerosis remains elusive. We review recent epidemiological studies of genetic and environmental factors that influence susceptibility to the disease and its clinical course. Recent findings: Genetic advances strengthen the association of multiple sclerosis with the human leukocyte antigen (HLA)-DRB1 allele and interferon-γ polymorphisms and suggest that apolipoprotein E alleles play an important role. In the environmental realm, nested case-control studies show that prior Epstein-Barr virus exposure is overrepresented in multiple sclerosis. Smoking has been associated with both risk of multiple sclerosis and progressive disease. Vitamin D deficiency might tie together environmental clues with higher multiple sclerosis prevalence rates; dietary vitamin supplementation is also associated with reduced multiple sclerosis risk. Natural history studies demonstrated dissociation between relapses and disease progression, facilitated the ability to distinguish neuromyelitis optica and related syndromes from typical multiple sclerosis, and spawned the exploration of large datasets to model long-term disease activity. Summary: Our understanding of the contributions of specific genetic and environmental factors that contribute to multiple sclerosis has improved. Further refinements will eventually allow powerful longitudinal studies to assess genetic and environmental interactions with implications for prediction of individual disease susceptibility, clinical course, and response to therapy.

AB - Purpose of review: The cause of multiple sclerosis remains elusive. We review recent epidemiological studies of genetic and environmental factors that influence susceptibility to the disease and its clinical course. Recent findings: Genetic advances strengthen the association of multiple sclerosis with the human leukocyte antigen (HLA)-DRB1 allele and interferon-γ polymorphisms and suggest that apolipoprotein E alleles play an important role. In the environmental realm, nested case-control studies show that prior Epstein-Barr virus exposure is overrepresented in multiple sclerosis. Smoking has been associated with both risk of multiple sclerosis and progressive disease. Vitamin D deficiency might tie together environmental clues with higher multiple sclerosis prevalence rates; dietary vitamin supplementation is also associated with reduced multiple sclerosis risk. Natural history studies demonstrated dissociation between relapses and disease progression, facilitated the ability to distinguish neuromyelitis optica and related syndromes from typical multiple sclerosis, and spawned the exploration of large datasets to model long-term disease activity. Summary: Our understanding of the contributions of specific genetic and environmental factors that contribute to multiple sclerosis has improved. Further refinements will eventually allow powerful longitudinal studies to assess genetic and environmental interactions with implications for prediction of individual disease susceptibility, clinical course, and response to therapy.

KW - Environmental factors

KW - Epidemiology

KW - Genetic factors

KW - Longitudinal studies

KW - Multiple sclerosis

KW - Natural history

UR - http://www.scopus.com/inward/record.url?scp=33744490350&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33744490350&partnerID=8YFLogxK

U2 - 10.1097/01.wco.0000227033.47458.82

DO - 10.1097/01.wco.0000227033.47458.82

M3 - Article

C2 - 16702830

AN - SCOPUS:33744490350

VL - 19

SP - 248

EP - 254

JO - Current Opinion in Neurology

JF - Current Opinion in Neurology

SN - 1350-7540

IS - 3

ER -