TY - JOUR
T1 - Epidemiology and Management of Hepatocellular Carcinoma
AU - Yang, Ju Dong
AU - Roberts, Lewis R.
N1 - Funding Information:
Secretarial support from Victoria Campion is gratefully acknowledged.
Funding Information:
Financial disclosure: This work was supported by grant no. CA100882 from the National Institutes of Health .
PY - 2010/12
Y1 - 2010/12
N2 - Hepatocellular carcinoma (HCC) is a major world health problem because of the high incidence and case fatality rate. In most patients, the diagnosis of HCC is made at an advanced stage, which limits the application of curative treatments. Most HCCs develop in patients with underlying chronic liver disease. Chronic viral hepatitis B and C are the major causes of liver cirrhosis and HCC. Recent improvements in treatment of viral hepatitis and in methods for surveillance and therapy for HCC have contributed to better survival of patients with HCC. This article reviews the epidemiology, cause, prevention, clinical manifestations, surveillance, diagnosis, and treatment approach for HCC.
AB - Hepatocellular carcinoma (HCC) is a major world health problem because of the high incidence and case fatality rate. In most patients, the diagnosis of HCC is made at an advanced stage, which limits the application of curative treatments. Most HCCs develop in patients with underlying chronic liver disease. Chronic viral hepatitis B and C are the major causes of liver cirrhosis and HCC. Recent improvements in treatment of viral hepatitis and in methods for surveillance and therapy for HCC have contributed to better survival of patients with HCC. This article reviews the epidemiology, cause, prevention, clinical manifestations, surveillance, diagnosis, and treatment approach for HCC.
KW - Hepatitis B
KW - Hepatitis C
KW - Liver transplantation
KW - Pathogenesis
KW - Radiofrequency ablation
KW - Transarterial chemoembolization
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U2 - 10.1016/j.idc.2010.07.004
DO - 10.1016/j.idc.2010.07.004
M3 - Review article
C2 - 20937457
AN - SCOPUS:77957734999
SN - 0891-5520
VL - 24
SP - 899
EP - 919
JO - Infectious Disease Clinics of North America
JF - Infectious Disease Clinics of North America
IS - 4
ER -