Epidemiology and Management of Hepatocellular Carcinoma

Ju Dong Yang, Lewis R. Roberts

Research output: Contribution to journalReview articlepeer-review

131 Scopus citations


Hepatocellular carcinoma (HCC) is a major world health problem because of the high incidence and case fatality rate. In most patients, the diagnosis of HCC is made at an advanced stage, which limits the application of curative treatments. Most HCCs develop in patients with underlying chronic liver disease. Chronic viral hepatitis B and C are the major causes of liver cirrhosis and HCC. Recent improvements in treatment of viral hepatitis and in methods for surveillance and therapy for HCC have contributed to better survival of patients with HCC. This article reviews the epidemiology, cause, prevention, clinical manifestations, surveillance, diagnosis, and treatment approach for HCC.

Original languageEnglish (US)
Pages (from-to)899-919
Number of pages21
JournalInfectious Disease Clinics of North America
Issue number4
StatePublished - Dec 2010


  • Hepatitis B
  • Hepatitis C
  • Liver transplantation
  • Pathogenesis
  • Radiofrequency ablation
  • Transarterial chemoembolization

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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