Epidemiology and clinical presentation

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Abstract

Renovascular disease appears to be increasing in prevalence, particularly in older subjects with atherosclerotic disease elsewhere. Its clinical manifestations and presentation are changing because of rapid advances in medical therapy and other comorbid events. Although fibromuscular dysplasia and other diseases affecting the renal artery can produce the syndrome of renovascular hypertension, atherosclerotic renal artery stenosis is the most common clinical entity. It can produce a spectrum of manifestations, ranging from asymptomatic ('incidental'), identified during angiographic evaluation of other conditions, to progressive hypertension to accelerated cardiovascular disease with pulmonary edema and advanced renal failure. With the widespread application of drugs which block the renin-angiotensin system, including angiotensin-converting enzyme inhibitors and angiotensin antagonists, many cases of renovascular hypertension remain unsuspected and never produce adverse effects. Clinicians need to be alert to the potential for disease progression, with the potential for total renal artery occlusion and/or loss of viable renal tissue. Selection of patients for renal revascularization depends on individual balance of risks and benefits regarding the likely outcomes regarding both improvements in blood pressure control and preservation of renal function. Copyright (C) 2000 by W.B. Saunders Company.

Original languageEnglish (US)
Pages (from-to)426-431
Number of pages6
JournalSeminars in Nephrology
Volume20
Issue number5
StatePublished - 2000

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Renovascular Hypertension
Epidemiology
Renal Artery
Kidney
Blood Preservation
Fibromuscular Dysplasia
Renal Artery Obstruction
Angiotensins
Pulmonary Edema
Renin-Angiotensin System
Angiotensin-Converting Enzyme Inhibitors
Patient Selection
Renal Insufficiency
Disease Progression
Cardiovascular Diseases
Blood Pressure
Hypertension
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Nephrology

Cite this

Epidemiology and clinical presentation. / Textor, Stephen C.

In: Seminars in Nephrology, Vol. 20, No. 5, 2000, p. 426-431.

Research output: Contribution to journalArticle

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