Epidemiologic aspects of Crohn's disease: A population based study in Olmsted County, Minnesota, 1943-1982

J. H. Gollop, S. F. Phillips, L. J. Melton, A. R. Zinsmeister

Research output: Contribution to journalArticle

208 Scopus citations

Abstract

The overall age and sex adjusted incidence of Crohn's disease among Olmsted County, Minnesota, residents was 4·0 per 100 000 person-years in the period 1943-1982. Ileitis, ileocolitis, and colitis each accounted for about one third of the 103 incidence cases. Incidence rates were greater in woman than men, were higher in the urban portions of the county, and rose over time. Overall, the natural history of Crohn's disease in the community may be milder than that reported for patients at referral centres, as over half of all patients had no complications and only a third required surgery for Crohn's disease. Only one developed adenocarcmoma of the colon (relative risk=2·0, NS). Survival was relatively unimpaired for the cohort but Crohn's disease may have played a role in half of the deaths. The prevalence of Crohn's disease was 90-5/100 000 population on 1 January 1980.

Original languageEnglish (US)
Pages (from-to)49-56
Number of pages8
JournalGut
Volume29
Issue number1
DOIs
StatePublished - Jan 1988

ASJC Scopus subject areas

  • Gastroenterology

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