Eosinophils regulate dendritic cells and Th2 pulmonary immune responses following allergen provocation

Elizabeth Jacobsen, Katie R. Zellner, Dana Colbert, Nancy A Lee, James J. Lee

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Reports have recently suggested that eosinophils have the potential to modulate allergen-dependent pulmonary immune responses. The studies presented expand these reports demonstrating in the mouse that eosinophils are required for the allergen-dependent Th2 pulmonary immune responses mediated by dendritic cells (DCs) and T lymphocytes. Specifically, the recruitment of peripheral eosinophils to the pulmonary lymphatic compartment(s) was required for the accumulation of myeloid DCs in draining lymph nodes and, in turn, Ag-specific T effector cell production. These effects on DCs and Ag-specific T cells did not require MHC class II expression on eosinophils, suggesting that these granulocytes have an accessory role as opposed to direct T cell stimulation. The data also showed that eosinophils uniquely suppress the DC-mediated production of Th17 and, to smaller degree, Th1 responses. The cumulative effect of these eosinophil-dependent immune mechanisms is to promote the Th2 polarization characteristic of the pulmonary microenvironment after allergen challenge.

Original languageEnglish (US)
Pages (from-to)6059-6068
Number of pages10
JournalJournal of Immunology
Volume187
Issue number11
DOIs
StatePublished - Dec 1 2011

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Eosinophils
Allergens
Dendritic Cells
Lung
T-Lymphocytes
Myeloid Cells
Granulocytes
Lymph Nodes

ASJC Scopus subject areas

  • Immunology

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Eosinophils regulate dendritic cells and Th2 pulmonary immune responses following allergen provocation. / Jacobsen, Elizabeth; Zellner, Katie R.; Colbert, Dana; Lee, Nancy A; Lee, James J.

In: Journal of Immunology, Vol. 187, No. 11, 01.12.2011, p. 6059-6068.

Research output: Contribution to journalArticle

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