TY - JOUR
T1 - Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age
AU - Brigger, Daniel
AU - Riether, Carsten
AU - van Brummelen, Robin
AU - Mosher, Kira I.
AU - Shiu, Alicia
AU - Ding, Zhaoqing
AU - Zbären, Noemi
AU - Gasser, Pascal
AU - Guntern, Pascal
AU - Yousef, Hanadie
AU - Castellano, Joseph M.
AU - Storni, Federico
AU - Graff-Radford, Neill
AU - Britschgi, Markus
AU - Grandgirard, Denis
AU - Hinterbrandner, Magdalena
AU - Siegrist, Mark
AU - Moullan, Norman
AU - Hofstetter, Willy
AU - Leib, Stephen L.
AU - Villiger, Peter M.
AU - Auwerx, Johan
AU - Villeda, Saul A.
AU - Wyss-Coray, Tony
AU - Noti, Mario
AU - Eggel, Alexander
N1 - Publisher Copyright:
© 2020, The Author(s), under exclusive licence to Springer Nature Limited.
PY - 2020/8/1
Y1 - 2020/8/1
N2 - Adipose tissue eosinophils (ATEs) are important in the control of obesity-associated inflammation and metabolic disease. However, the way in which ageing impacts the regulatory role of ATEs remains unknown. Here, we show that ATEs undergo major age-related changes in distribution and function associated with impaired adipose tissue homeostasis and systemic low-grade inflammation in both humans and mice. We find that exposure to a young systemic environment partially restores ATE distribution in aged parabionts and reduces adipose tissue inflammation. Approaches to restore ATE distribution using adoptive transfer of eosinophils from young mice into aged recipients proved sufficient to dampen age-related local and systemic low-grade inflammation. Importantly, restoration of a youthful systemic milieu by means of eosinophil transfers resulted in systemic rejuvenation of the aged host, manifesting in improved physical and immune fitness that was partially mediated by eosinophil-derived IL-4. Together, these findings support a critical function of adipose tissue as a source of pro-ageing factors and uncover a new role of eosinophils in promoting healthy ageing by sustaining adipose tissue homeostasis.
AB - Adipose tissue eosinophils (ATEs) are important in the control of obesity-associated inflammation and metabolic disease. However, the way in which ageing impacts the regulatory role of ATEs remains unknown. Here, we show that ATEs undergo major age-related changes in distribution and function associated with impaired adipose tissue homeostasis and systemic low-grade inflammation in both humans and mice. We find that exposure to a young systemic environment partially restores ATE distribution in aged parabionts and reduces adipose tissue inflammation. Approaches to restore ATE distribution using adoptive transfer of eosinophils from young mice into aged recipients proved sufficient to dampen age-related local and systemic low-grade inflammation. Importantly, restoration of a youthful systemic milieu by means of eosinophil transfers resulted in systemic rejuvenation of the aged host, manifesting in improved physical and immune fitness that was partially mediated by eosinophil-derived IL-4. Together, these findings support a critical function of adipose tissue as a source of pro-ageing factors and uncover a new role of eosinophils in promoting healthy ageing by sustaining adipose tissue homeostasis.
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U2 - 10.1038/s42255-020-0228-3
DO - 10.1038/s42255-020-0228-3
M3 - Article
C2 - 32694825
AN - SCOPUS:85087616222
SN - 2522-5812
VL - 2
SP - 688
EP - 702
JO - Nature Metabolism
JF - Nature Metabolism
IS - 8
ER -