Eosinophils Mediate Tissue Injury in the Autoimmune Skin Disease Bullous Pemphigoid

Lan Lin, Bin Jin Hwang, Donna A. Culton, Ning Li, Susan Burette, Beverly H. Koller, Kelly A. Messingham, Janet A. Fairley, James J. Lee, Russell P. Hall, Lijia An, Luis A. Diaz, Zhi Liu

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Eosinophils are typically associated with unique inflammatory settings, including allergic inflammation and helminth infections. However, new information suggests that eosinophils contribute more broadly to inflammatory responses and participate in local immune regulation and the tissue remodeling/repair events linked with a variety of diseases. Eosinophilic infiltration has long been a histologic hallmark of bullous pemphigoid (BP), a subepidermal autoimmune blistering disease characterized by autoantibodies directed against basement membrane protein BP180. However, the exact role of eosinophils in disease pathogenesis remains largely unknown. We show here that eosinophils are necessary for IgE autoantibody-mediated BP blister formation in a humanized IgE receptor mouse model of BP. Disease severity is IgE dose dependent and correlates with the degree of eosinophil infiltration in the skin. Furthermore, IgE autoantibodies fail to induce BP in eosinophil-deficient mice, confirming that eosinophils are required for IgE-mediated tissue injury. Thus, eosinophils provide the cellular link between IgE autoantibodies and skin blistering in this murine model of BP. These findings suggest a role for eosinophils in autoimmune disease and have important implications for the treatment of BP and other antibody-mediated inflammatory and autoimmune diseases.

Original languageEnglish (US)
Pages (from-to)1032-1043
Number of pages12
JournalJournal of Investigative Dermatology
Volume138
Issue number5
DOIs
StatePublished - May 1 2018

Fingerprint

Bullous Pemphigoid
Skin Diseases
Eosinophils
Autoimmune Diseases
Skin
Immunoglobulin E
Tissue
Autoantibodies
Wounds and Injuries
Infiltration
IgE Receptors
Membrane Proteins
Repair
Helminths
Blister
Basement Membrane
Antibodies
Inflammation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

Cite this

Lin, L., Hwang, B. J., Culton, D. A., Li, N., Burette, S., Koller, B. H., ... Liu, Z. (2018). Eosinophils Mediate Tissue Injury in the Autoimmune Skin Disease Bullous Pemphigoid. Journal of Investigative Dermatology, 138(5), 1032-1043. https://doi.org/10.1016/j.jid.2017.11.031

Eosinophils Mediate Tissue Injury in the Autoimmune Skin Disease Bullous Pemphigoid. / Lin, Lan; Hwang, Bin Jin; Culton, Donna A.; Li, Ning; Burette, Susan; Koller, Beverly H.; Messingham, Kelly A.; Fairley, Janet A.; Lee, James J.; Hall, Russell P.; An, Lijia; Diaz, Luis A.; Liu, Zhi.

In: Journal of Investigative Dermatology, Vol. 138, No. 5, 01.05.2018, p. 1032-1043.

Research output: Contribution to journalArticle

Lin, L, Hwang, BJ, Culton, DA, Li, N, Burette, S, Koller, BH, Messingham, KA, Fairley, JA, Lee, JJ, Hall, RP, An, L, Diaz, LA & Liu, Z 2018, 'Eosinophils Mediate Tissue Injury in the Autoimmune Skin Disease Bullous Pemphigoid', Journal of Investigative Dermatology, vol. 138, no. 5, pp. 1032-1043. https://doi.org/10.1016/j.jid.2017.11.031
Lin, Lan ; Hwang, Bin Jin ; Culton, Donna A. ; Li, Ning ; Burette, Susan ; Koller, Beverly H. ; Messingham, Kelly A. ; Fairley, Janet A. ; Lee, James J. ; Hall, Russell P. ; An, Lijia ; Diaz, Luis A. ; Liu, Zhi. / Eosinophils Mediate Tissue Injury in the Autoimmune Skin Disease Bullous Pemphigoid. In: Journal of Investigative Dermatology. 2018 ; Vol. 138, No. 5. pp. 1032-1043.
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