Eosinophils, but not eosinophil peroxidase or major basic protein, are important for host protection in experimental Brugia pahangi infection

Thirumalai Ramalingam, Patricia Porte, James Lee, T. V. Rajan

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

The attenuation of eosinophilia by the administration of monoclonal antibodies to CCR3 consistently correlates with impairment in worm elimination following primary intraperitoneal Brugia pahangi infections in mice. Host protection was unimpaired in mice deficient in eosinophil peroxidase (EPO) or major basic protein 1 (MBP-1), suggesting that eosinophils are essential in host protection but that neither EPO nor MBP-1 alone is.

Original languageEnglish (US)
Pages (from-to)8442-8443
Number of pages2
JournalInfection and Immunity
Volume73
Issue number12
DOIs
StatePublished - Dec 2005

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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