Abstract
The attenuation of eosinophilia by the administration of monoclonal antibodies to CCR3 consistently correlates with impairment in worm elimination following primary intraperitoneal Brugia pahangi infections in mice. Host protection was unimpaired in mice deficient in eosinophil peroxidase (EPO) or major basic protein 1 (MBP-1), suggesting that eosinophils are essential in host protection but that neither EPO nor MBP-1 alone is.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 8442-8443 |
| Number of pages | 2 |
| Journal | Infection and Immunity |
| Volume | 73 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 2005 |
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ASJC Scopus subject areas
- Immunology
Cite this
Eosinophils, but not eosinophil peroxidase or major basic protein, are important for host protection in experimental Brugia pahangi infection. / Ramalingam, Thirumalai; Porte, Patricia; Lee, James; Rajan, T. V.
In: Infection and Immunity, Vol. 73, No. 12, 12.2005, p. 8442-8443.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Eosinophils, but not eosinophil peroxidase or major basic protein, are important for host protection in experimental Brugia pahangi infection
AU - Ramalingam, Thirumalai
AU - Porte, Patricia
AU - Lee, James
AU - Rajan, T. V.
PY - 2005/12
Y1 - 2005/12
N2 - The attenuation of eosinophilia by the administration of monoclonal antibodies to CCR3 consistently correlates with impairment in worm elimination following primary intraperitoneal Brugia pahangi infections in mice. Host protection was unimpaired in mice deficient in eosinophil peroxidase (EPO) or major basic protein 1 (MBP-1), suggesting that eosinophils are essential in host protection but that neither EPO nor MBP-1 alone is.
AB - The attenuation of eosinophilia by the administration of monoclonal antibodies to CCR3 consistently correlates with impairment in worm elimination following primary intraperitoneal Brugia pahangi infections in mice. Host protection was unimpaired in mice deficient in eosinophil peroxidase (EPO) or major basic protein 1 (MBP-1), suggesting that eosinophils are essential in host protection but that neither EPO nor MBP-1 alone is.
UR - http://www.scopus.com/inward/record.url?scp=28444446700&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=28444446700&partnerID=8YFLogxK
U2 - 10.1128/IAI.73.12.8442-8443.2005
DO - 10.1128/IAI.73.12.8442-8443.2005
M3 - Article
C2 - 16299347
AN - SCOPUS:28444446700
VL - 73
SP - 8442
EP - 8443
JO - Infection and Immunity
JF - Infection and Immunity
SN - 0019-9567
IS - 12
ER -