Eosinophils and asthma

Elizabeth A. Jacobsen, Sergei I. Ochkur, Nancy A. Lee, James J. Lee

Research output: Contribution to journalReview article

55 Scopus citations

Abstract

Recruitment and activation of eosinophils into the airways of asthma patients is suggested to be a contributing causative agent in the histopathologies and lung dysfunction that are characteristic of asthma. Recent studies in mouse models of asthma and in human patients implicate eosinophils in immune regulation and remodeling in the lung in addition to their hypothesized role as destructive agents. Specifically, eosinophils not only participate in release of granule proteins, lipid mediators, reactive oxygen species, cytokines, and growth factors but also function through complex cell-cell interactions to elicit chronic T helper 2 inflammation in the lung. This review highlights the roles of eosinophils in asthma.

Original languageEnglish (US)
Pages (from-to)18-26
Number of pages9
JournalCurrent Allergy and Asthma Reports
Volume7
Issue number1
DOIs
StatePublished - Apr 1 2007

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine

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