Eosinophilic oesophagitis in adults - A rising epidemic

Shabana F. Pasha, Michael D. Crowell, Jeffrey A. Alexander, Lucinda A. Harris, Sami R. Achem, Gianrico Farrugia, James J. Lee, Dana M. Thompson, Kee Wook Jung, Hirohita Kita, Karthik Ravi, Vikneswaran Namasivayam, Hack Jae Kim, David E. Fleischer, Virender K. Sharma, Yvonne Romero

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Eosinophilic oesophagitis (EoE) is a clinicopathological disorder of the oesophagus, which typically affects young males, and is characterised by clinical symptoms of dysphagia and food impaction. The diagnosis is established by histopathological findings of >15 intraepithelial eosinophils per high power field (eos/HPF) in the oesophageal mucosa. The aetiopathogenesis of this disorder remains unknown, and the earlier concept that EoE is a consequence of gastroesophageal reflux disease (GERD) is under debate. It is now considered to be a separate entity that results from allergic and immunological responses to environmental allergens. Typical endoscopic features include oesophageal corrugations and linear furrows, but the disorder should be suspected in the appropriate clinical setting even in patients with an oesophagus that appears normal. The mainstay of treatment includes anti-inflammatory medications (steroids) and avoidance of allergens. Endoscopic dilation is an option in patients who do not respond to medical management. With the increasing comprehension of the immunopathogenesis of this disorder, immunomodulators and other novel agents may be increasingly utilised in the future, in patients who are refractory to conventional medical management.

Original languageEnglish (US)
Pages (from-to)14-20
Number of pages7
JournalEuropean Gastroenterology and Hepatology Review
Volume7
Issue number1
StatePublished - Feb 2011

Keywords

  • Corrugated oesophagus
  • Eosinophilia
  • Eosinophilic microabscesses
  • Eosinophilic oesophagitis
  • Feline oesophagus
  • Food impaction
  • Gastroesophageal reflux disease
  • Linear furrows
  • Oesophageal dilation

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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