Eosinophilic leukemia

A myeloproliferative disorder distinct from the hypereosinophilic syndrome

B. D. Kueck, R. E. Smith, J. Parkin, L. C. Peterson, C. A. Hanson

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Evidence to support the existence of eosinophilic leukemia (EL) as an autonomous eosinophilic proliferation analogous to other myeloproliferative disorders has been somewhat confusing. Partially obscuring the existence of EL as a distinct entity is the proposal that EL merely represents a clinically aggressive form of hypereosinophilic syndrome. This report details the clinical and pathologic findings in a case of EL. The presence of trisomy 8 and trisomy 21; morphologic, cytochemical, and ultrastructural findings of granular abnormalities and nuclear/cytoplasmic dysynchrony; and a clinical course similar to that of other myeloproliferative disorders support the existence of EL as a rare but distinct entity within the spectrum of myeloproliferative diseases.

Original languageEnglish (US)
Pages (from-to)195-205
Number of pages11
JournalHematologic Pathology
Volume5
Issue number4
StatePublished - 1991
Externally publishedYes

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Hypereosinophilic Syndrome
Myeloproliferative Disorders
Down Syndrome

ASJC Scopus subject areas

  • Hematology
  • Pathology and Forensic Medicine

Cite this

Kueck, B. D., Smith, R. E., Parkin, J., Peterson, L. C., & Hanson, C. A. (1991). Eosinophilic leukemia: A myeloproliferative disorder distinct from the hypereosinophilic syndrome. Hematologic Pathology, 5(4), 195-205.

Eosinophilic leukemia : A myeloproliferative disorder distinct from the hypereosinophilic syndrome. / Kueck, B. D.; Smith, R. E.; Parkin, J.; Peterson, L. C.; Hanson, C. A.

In: Hematologic Pathology, Vol. 5, No. 4, 1991, p. 195-205.

Research output: Contribution to journalArticle

Kueck, BD, Smith, RE, Parkin, J, Peterson, LC & Hanson, CA 1991, 'Eosinophilic leukemia: A myeloproliferative disorder distinct from the hypereosinophilic syndrome', Hematologic Pathology, vol. 5, no. 4, pp. 195-205.
Kueck, B. D. ; Smith, R. E. ; Parkin, J. ; Peterson, L. C. ; Hanson, C. A. / Eosinophilic leukemia : A myeloproliferative disorder distinct from the hypereosinophilic syndrome. In: Hematologic Pathology. 1991 ; Vol. 5, No. 4. pp. 195-205.
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