Eosinophilic Inflammation in Peritoneal Fibrosis Patients Undergoing Peritoneal Dialysis

Takehito Kobayashi, Toru Noguchi, Kohei Saito, Fumitaka Shirasaki, Hirohito Kita, Makoto Nagata, Hirokazu Okada, Hidetomo Nakamoto

Research output: Contribution to journalArticle

Abstract

Background: Renal replacement therapy is vital for patients with chronic renal failure. Each type of renal replacement therapy has its own characteristics, and patients select it according on their living environment or conception of quality of life. Under the recent medical environment in Japan, economic burden of dialysis is another concern. For patients with chronic renal failure, the outcome of dialysis is vital. How to prevent or control side effects and complications is also important. One type of dialysis treatment is called peritoneal dialysis. Complications from long-term peritoneal dialysis include encapsulating peritoneal sclerosis (EPS), which can lead to life-threatening intestinal obstruction. Here, we hope to prevent the incidence of EPS through examining new possibilities in the pathogenesis during peritoneal dialysis and considering countermeasures. Summary: Membrane dialysis is a treatment methodology that makes use of the semipermeable function of body membranes. When the composition of the peritoneal dialysate is adjusted, it also removes waste products and adjusts water level. Chemical stimuli of peritoneal dialysate on peritonea can trigger inflammation and, when long-lasting, the latter is considered to cause EPS. For the body, chemical stimuli are invasive. Damaged body tissues have a capacity to repair themselves. The innate immune system is known to work in response to nonspecific stimulation, and so it is well conceivable that it is active in the abdominal cavity under peritoneal dialysis. Among many inflammatory cells involved in the innate immune system, we focus on the role of eosinophils to consider the possibility of unknown pathogenesis.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalContributions to Nephrology
Volume196
DOIs
StatePublished - Jan 1 2018

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Peritoneal Fibrosis
Peritoneal Dialysis
Dialysis
Inflammation
Renal Replacement Therapy
Dialysis Solutions
Chronic Kidney Failure
Immune System
Waste Products
Membranes
Abdominal Cavity
Intestinal Obstruction
Peritoneum
Eosinophils
Japan
Economics
Quality of Life
Water
Incidence
Therapeutics

ASJC Scopus subject areas

  • Nephrology

Cite this

Eosinophilic Inflammation in Peritoneal Fibrosis Patients Undergoing Peritoneal Dialysis. / Kobayashi, Takehito; Noguchi, Toru; Saito, Kohei; Shirasaki, Fumitaka; Kita, Hirohito; Nagata, Makoto; Okada, Hirokazu; Nakamoto, Hidetomo.

In: Contributions to Nephrology, Vol. 196, 01.01.2018, p. 1-4.

Research output: Contribution to journalArticle

Kobayashi, T, Noguchi, T, Saito, K, Shirasaki, F, Kita, H, Nagata, M, Okada, H & Nakamoto, H 2018, 'Eosinophilic Inflammation in Peritoneal Fibrosis Patients Undergoing Peritoneal Dialysis', Contributions to Nephrology, vol. 196, pp. 1-4. https://doi.org/10.1159/000485689
Kobayashi, Takehito ; Noguchi, Toru ; Saito, Kohei ; Shirasaki, Fumitaka ; Kita, Hirohito ; Nagata, Makoto ; Okada, Hirokazu ; Nakamoto, Hidetomo. / Eosinophilic Inflammation in Peritoneal Fibrosis Patients Undergoing Peritoneal Dialysis. In: Contributions to Nephrology. 2018 ; Vol. 196. pp. 1-4.
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