Eosinophilic granulomatosis with polyangiitis and diffuse gastrointestinal involvement

Diana L. Franco; Kevin Ruff; Lester Mertz; Dora M. Lam-Himlin; Russell Heigh

doi:10.1159/000369129

Eosinophilic granulomatosis with polyangiitis and diffuse gastrointestinal involvement

Diana L. Franco, Kevin Ruff, Lester Mertz, Dora M. Lam-Himlin, Russell Heigh

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Eosinophilic granulomatosis with polyangiitis (EGPA), formerly named Churg-Strauss syndrome, is a rare systemic small- and medium-sized-vessel vasculitis, characterized by the presence of severe asthma as well as blood and tissue eosinophilia. Gastrointestinal (GI) symptoms, like diarrhea and abdominal pain, are common; however, there are few reports of histologic evidence of GI involvement. We report the case of a patient on treatment for EGPA who presented with recurrent small bowel obstruction and choledocholithiasis. Biopsies of the esophagus, small bowel and common bile duct showed diffuse eosinophilia, with clear EGPA in the GI tract. Improved awareness of GI EGPA may allow for timely management of this disorder.

Original language	English (US)
Pages (from-to)	329-336
Number of pages	8
Journal	Case Reports in Gastroenterology
Volume	8
Issue number	3
DOIs	https://doi.org/10.1159/000369129
State	Published - Apr 12 2014

Keywords

Cholangitis
Eosinophilic granulomatosis with polyangiitis
Gastrointestinal tract
Small bowel obstruction

ASJC Scopus subject areas

Gastroenterology

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10.1159/000369129

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title = "Eosinophilic granulomatosis with polyangiitis and diffuse gastrointestinal involvement",

abstract = "Eosinophilic granulomatosis with polyangiitis (EGPA), formerly named Churg-Strauss syndrome, is a rare systemic small- and medium-sized-vessel vasculitis, characterized by the presence of severe asthma as well as blood and tissue eosinophilia. Gastrointestinal (GI) symptoms, like diarrhea and abdominal pain, are common; however, there are few reports of histologic evidence of GI involvement. We report the case of a patient on treatment for EGPA who presented with recurrent small bowel obstruction and choledocholithiasis. Biopsies of the esophagus, small bowel and common bile duct showed diffuse eosinophilia, with clear EGPA in the GI tract. Improved awareness of GI EGPA may allow for timely management of this disorder.",

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AU - Franco, Diana L.

AU - Ruff, Kevin

AU - Mertz, Lester

AU - Lam-Himlin, Dora M.

AU - Heigh, Russell

PY - 2014/4/12

Y1 - 2014/4/12

N2 - Eosinophilic granulomatosis with polyangiitis (EGPA), formerly named Churg-Strauss syndrome, is a rare systemic small- and medium-sized-vessel vasculitis, characterized by the presence of severe asthma as well as blood and tissue eosinophilia. Gastrointestinal (GI) symptoms, like diarrhea and abdominal pain, are common; however, there are few reports of histologic evidence of GI involvement. We report the case of a patient on treatment for EGPA who presented with recurrent small bowel obstruction and choledocholithiasis. Biopsies of the esophagus, small bowel and common bile duct showed diffuse eosinophilia, with clear EGPA in the GI tract. Improved awareness of GI EGPA may allow for timely management of this disorder.

AB - Eosinophilic granulomatosis with polyangiitis (EGPA), formerly named Churg-Strauss syndrome, is a rare systemic small- and medium-sized-vessel vasculitis, characterized by the presence of severe asthma as well as blood and tissue eosinophilia. Gastrointestinal (GI) symptoms, like diarrhea and abdominal pain, are common; however, there are few reports of histologic evidence of GI involvement. We report the case of a patient on treatment for EGPA who presented with recurrent small bowel obstruction and choledocholithiasis. Biopsies of the esophagus, small bowel and common bile duct showed diffuse eosinophilia, with clear EGPA in the GI tract. Improved awareness of GI EGPA may allow for timely management of this disorder.

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KW - Gastrointestinal tract

KW - Small bowel obstruction

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Eosinophilic granulomatosis with polyangiitis and diffuse gastrointestinal involvement

Abstract

Keywords

ASJC Scopus subject areas

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