Eosinophilic fasciitis: Clinical spectrum and therapeutic response in 52 cases

Sharad Lakhanpal, William W. Ginsburg, Clement Michet, John A. Doyle, S. Breanndan Moore

Research output: Contribution to journalArticle

279 Citations (Scopus)

Abstract

The clinical course of 52 cases with eosinophilic fasciitis observed at the Mayo Clinic has been described. Cutaneous changes included pitting edema, peau d'orange, and induration, and may affect virtually any body surface area. In addition, localized morphea was present in 15 cases. Arthritis was observed in 21 patients; 29 patients had flexion contractures and 12 had carpal tunnel syndrome. Associated hematologic diseases were found in five patients; thrombocytopenia in two, myeloproliferative disorder in one, myelomonocytic leukemia in one, and chronic lymphocytic leukemia in one. Peripheral blood eosinophilia was noted in 33 of 52 patients, hypergammaglobulinemia was noted in 17 of 49, and elevated sedimentation rate was noted in 15 of 52. Nonspecific EMG changes were seen in 11 of 15 patients. None had clinical involvement of the kidneys, lungs, or heart. No significant association between any HLA-A, -B, or -DR and eosinophilic fasciitis was seen. Prednisone and hydroxychloroquine seemed equally beneficial in treatment; however, some cases showed spontaneous recovery, making evaluation of therapeutic efficacy difficult. Relapses occurred in some cases.

Original languageEnglish (US)
Pages (from-to)221-231
Number of pages11
JournalSeminars in Arthritis and Rheumatism
Volume17
Issue number4
DOIs
StatePublished - Jan 1 1988
Externally publishedYes

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Localized Scleroderma
Hydroxychloroquine
Hypergammaglobulinemia
Therapeutics
Myeloproliferative Disorders
Carpal Tunnel Syndrome
HLA-A Antigens
HLA-B Antigens
Hematologic Diseases
Body Surface Area
Eosinophilia
Contracture
B-Cell Chronic Lymphocytic Leukemia
Prednisone
Thrombocytopenia
Arthritis
Edema
Leukemia
Eosinophilic Fasciitis
Kidney

ASJC Scopus subject areas

  • Rheumatology
  • Anesthesiology and Pain Medicine

Cite this

Eosinophilic fasciitis : Clinical spectrum and therapeutic response in 52 cases. / Lakhanpal, Sharad; Ginsburg, William W.; Michet, Clement; Doyle, John A.; Moore, S. Breanndan.

In: Seminars in Arthritis and Rheumatism, Vol. 17, No. 4, 01.01.1988, p. 221-231.

Research output: Contribution to journalArticle

Lakhanpal, Sharad ; Ginsburg, William W. ; Michet, Clement ; Doyle, John A. ; Moore, S. Breanndan. / Eosinophilic fasciitis : Clinical spectrum and therapeutic response in 52 cases. In: Seminars in Arthritis and Rheumatism. 1988 ; Vol. 17, No. 4. pp. 221-231.
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