Eosinophilic esophagitis

Overview of clinical management

Alain M. Schoepfer, Ikuo Hirano, David A Katzka

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A validated disease-specific symptom-assessment tool for eosinophilic esophagitis (EoE) has yet to be approved by regulatory authorities for use in clinical trials. Relevant end points for daily practice include EoE-related symptoms and esophageal eosinophilic inflammation. Endoscopic features should also be taken into account when establishing a therapy plan. A reasonable clinical goal is to achieve a reduction in EoE-related symptoms and esophageal eosinophilic inflammation. Evidence is increasing to support an anti-inflammatory maintenance therapy, as this can reduce esophageal remodeling. In EoE patients in clinical remission, annual disease monitoring with symptom, endoscopic, and histologic assessments of sustained treatment response is recommended.

Original languageEnglish (US)
Pages (from-to)329-344
Number of pages16
JournalGastroenterology Clinics of North America
Volume43
Issue number2
DOIs
StatePublished - 2014

Fingerprint

Eosinophilic Esophagitis
Inflammation
Symptom Assessment
Anti-Inflammatory Agents
Therapeutics
Clinical Trials

Keywords

  • Dysphagia
  • Eosinophilic esophagitis
  • Gastroesophageal reflux disease
  • Patient-reported outcomes
  • Treatment end points

ASJC Scopus subject areas

  • Gastroenterology
  • Medicine(all)

Cite this

Eosinophilic esophagitis : Overview of clinical management. / Schoepfer, Alain M.; Hirano, Ikuo; Katzka, David A.

In: Gastroenterology Clinics of North America, Vol. 43, No. 2, 2014, p. 329-344.

Research output: Contribution to journalArticle

Schoepfer, Alain M. ; Hirano, Ikuo ; Katzka, David A. / Eosinophilic esophagitis : Overview of clinical management. In: Gastroenterology Clinics of North America. 2014 ; Vol. 43, No. 2. pp. 329-344.
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