Eosinophilia: Secondary, clonal and idiopathic

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200 Scopus citations

Abstract

Blood eosinophilia signifies either a cytokine-mediated reactive phenomenon (secondary) or an integral phenotype of an underlying haematological neoplasm (primary). Secondary eosinophilia is usually associated with parasitosis in Third World countries and allergic conditions in the West. Primary eosinophilia is operationally classified as being clonal or idiopathic, depending on the respective presence or absence of a molecular, cytogenetic or histological evidence for a myeloid malignancy. The current communication features a comprehensive clinical summary of both secondary and primary eosinophilic disorders with emphasis on recent developments in molecular pathogenesis and treatment.

Original languageEnglish (US)
Pages (from-to)468-492
Number of pages25
JournalBritish journal of haematology
Volume133
Issue number5
DOIs
StatePublished - Jun 2006

Keywords

  • Diagnosis
  • FIP1L1-PDGFRA
  • Hypereosinophilic syndrome
  • Imatinib mesylate
  • Treatment

ASJC Scopus subject areas

  • Hematology

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