Eosinophilia in bronchoalveolar lavage fluid and architectural destruction are features of desquamative interstitial pneumonia

Y. Kawabata, T. Takemura, A. Hebisawa, T. Ogura, T. Yamaguchi, T. Kuriyama, S. Nagai, M. Sakatani, K. Chida, F. Sakai, J. Park, T. V. Colby

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Aims: Desquamative interstitial pneumonia (DIP) is a rare pattern of diffuse parenchymal lung disease known to overlap with respiratory bronchiolitis-interstitial lung disease (RB-ILD). The aim was to review biopsy-proven cases of DIP to investigate further the clinical, imaging and histological features of this disease. Methods and results: Twenty patients fulfilled the pathological criteria: 19 men and one woman with a mean age of 54 years. Clinical features, bronchoalveolar lavage (BAL) data, radiological findings, pathological findings other than criteria, effect of therapy and outcome were examined. The BAL data for 17 cases revealed marked eosinophilia (mean 18%) and moderate neutrophilia (mean 11%). Computed tomography in 17 patients showed peripheral involvement in all cases with a clear margin in 64% and thin-walled cysts in 35% of cases. Additional pathological features were a distinct lobular distribution (70%) and architectural destruction (70%) with cyst formation (55%). Eighteen of the 19 patients (95%) improved under steroid pulse and/or oral therapy. Sixteen subjects (80%) are alive, three died of other diseases and one died of DIP 74 months after the diagnosis. Percent vital capacity increased significantly and new thin-walled cysts appeared in one case. Conclusions: BAL eosinophilia, lobular distribution and architectural destruction with cyst formation are characteristic features of DIP.

Original languageEnglish (US)
Pages (from-to)194-202
Number of pages9
JournalHistopathology
Volume52
Issue number2
DOIs
StatePublished - Jan 2008

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Interstitial Lung Diseases
Bronchoalveolar Lavage Fluid
Eosinophilia
Cysts
Bronchoalveolar Lavage
Bronchiolitis
Vital Capacity
Steroids
Tomography
Biopsy
Therapeutics

Keywords

  • Bronchoalveolar lavage
  • Desquamative interstitial pneumonia
  • Surgical lung biopsy

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Cell Biology

Cite this

Kawabata, Y., Takemura, T., Hebisawa, A., Ogura, T., Yamaguchi, T., Kuriyama, T., ... Colby, T. V. (2008). Eosinophilia in bronchoalveolar lavage fluid and architectural destruction are features of desquamative interstitial pneumonia. Histopathology, 52(2), 194-202. https://doi.org/10.1111/j.1365-2559.2007.02930.x

Eosinophilia in bronchoalveolar lavage fluid and architectural destruction are features of desquamative interstitial pneumonia. / Kawabata, Y.; Takemura, T.; Hebisawa, A.; Ogura, T.; Yamaguchi, T.; Kuriyama, T.; Nagai, S.; Sakatani, M.; Chida, K.; Sakai, F.; Park, J.; Colby, T. V.

In: Histopathology, Vol. 52, No. 2, 01.2008, p. 194-202.

Research output: Contribution to journalArticle

Kawabata, Y, Takemura, T, Hebisawa, A, Ogura, T, Yamaguchi, T, Kuriyama, T, Nagai, S, Sakatani, M, Chida, K, Sakai, F, Park, J & Colby, TV 2008, 'Eosinophilia in bronchoalveolar lavage fluid and architectural destruction are features of desquamative interstitial pneumonia', Histopathology, vol. 52, no. 2, pp. 194-202. https://doi.org/10.1111/j.1365-2559.2007.02930.x
Kawabata, Y. ; Takemura, T. ; Hebisawa, A. ; Ogura, T. ; Yamaguchi, T. ; Kuriyama, T. ; Nagai, S. ; Sakatani, M. ; Chida, K. ; Sakai, F. ; Park, J. ; Colby, T. V. / Eosinophilia in bronchoalveolar lavage fluid and architectural destruction are features of desquamative interstitial pneumonia. In: Histopathology. 2008 ; Vol. 52, No. 2. pp. 194-202.
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