TY - JOUR
T1 - Eosinophil Knockout Humans
T2 - Uncovering the Role of Eosinophils through Eosinophil-Directed Biological Therapies
AU - Jacobsen, Elizabeth A.
AU - Jackson, David J.
AU - Heffler, Enrico
AU - Mathur, Sameer K.
AU - Bredenoord, Albert J.
AU - Pavord, Ian D.
AU - Akuthota, Praveen
AU - Roufosse, Florence
AU - Rothenberg, Marc E.
N1 - Publisher Copyright:
© 2021 Annual Reviews Inc.. All rights reserved.
PY - 2021/4/26
Y1 - 2021/4/26
N2 - The enigmatic eosinophil has emerged as an exciting component of the immune system, involved in a plethora of homeostatic and inflammatory responses. Substantial progress has been achieved through experimental systems manipulating eosinophils in vivo, initially in mice and more recently in humans. Researchers using eosinophil knockout mice have identified a contributory role for eosinophils in basal and inflammatory processes and protective immunity. Primarily fueled by the purported proinflammatory role of eosinophils in eosinophil-associated diseases, a series of anti-eosinophil therapeutics have emerged as a new class of drugs. These agents, which dramatically deplete eosinophils, provide a valuable opportunity to characterize the consequences of eosinophil knockout humans. Herein, we comparatively describe mouse and human eosinophil knockouts. We put forth the view that human eosinophils negatively contribute to a variety of diseases and, unlike mouse eosinophils, do not yet have an identified role in physiological health; thus, clarifying all roles of eosinophils remains an ongoing pursuit.
AB - The enigmatic eosinophil has emerged as an exciting component of the immune system, involved in a plethora of homeostatic and inflammatory responses. Substantial progress has been achieved through experimental systems manipulating eosinophils in vivo, initially in mice and more recently in humans. Researchers using eosinophil knockout mice have identified a contributory role for eosinophils in basal and inflammatory processes and protective immunity. Primarily fueled by the purported proinflammatory role of eosinophils in eosinophil-associated diseases, a series of anti-eosinophil therapeutics have emerged as a new class of drugs. These agents, which dramatically deplete eosinophils, provide a valuable opportunity to characterize the consequences of eosinophil knockout humans. Herein, we comparatively describe mouse and human eosinophil knockouts. We put forth the view that human eosinophils negatively contribute to a variety of diseases and, unlike mouse eosinophils, do not yet have an identified role in physiological health; thus, clarifying all roles of eosinophils remains an ongoing pursuit.
KW - IL-5
KW - biologic agents
KW - eosinophil
KW - eosinophil knockout
KW - eosinophil-associated diseases
KW - eosinophil-deficient mice
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UR - http://www.scopus.com/inward/citedby.url?scp=85104994903&partnerID=8YFLogxK
U2 - 10.1146/annurev-immunol-093019-125918
DO - 10.1146/annurev-immunol-093019-125918
M3 - Review article
C2 - 33646859
AN - SCOPUS:85104994903
SN - 0732-0582
VL - 39
SP - 719
EP - 757
JO - Annual Review of Immunology
JF - Annual Review of Immunology
ER -