Eosinophil-derived IL-10 supports chronic nematode infection

Lu Huang, Nebiat G. Gebreselassie, Lucille F. Gagliardo, Maura C. Ruyechan, Nancy A Lee, James J. Lee, Judith A. Appleton

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Eosinophilia is a feature of the host immune response that distinguishes parasitic worms from other pathogens, yet a discrete function for eosinophils in worm infection has been elusive. The aim of this study was to clarify the mechanism(s) underlying the striking and unexpected observation that eosinophils protect intracellular, muscle-stage Trichinella spiralis larvae against NO-mediated killing. Our findings indicate that eosinophils are specifically recruited to sites of infection at the earliest stage of muscle infection, consistent with a local response to injury. Early recruitment is essential for larval survival. By producing IL-10 at the initiation of infection, eosinophils expand IL-10+ myeloid dendritic cells and CD4+ IL-10+ T lymphocytes that inhibit inducible NO synthase (iNOS) expression and protect intracellular larvae. The results document a novel immunoregulatory function of eosinophils in helminth infection, in which eosinophil-derived IL-10 drives immune responses that eventually limit local NO production. In this way, the parasite co-opts an immune response in a way that enhances its own survival.

Original languageEnglish (US)
Pages (from-to)4178-4187
Number of pages10
JournalJournal of Immunology
Volume193
Issue number8
DOIs
StatePublished - Oct 15 2014

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Nematode Infections
Eosinophils
Interleukin-10
Infection
Helminths
Larva
Trichinella spiralis
Muscles
Eosinophilia
Myeloid Cells
Nitric Oxide Synthase
Dendritic Cells
Parasites
Observation
T-Lymphocytes
Wounds and Injuries

ASJC Scopus subject areas

  • Immunology
  • Medicine(all)

Cite this

Huang, L., Gebreselassie, N. G., Gagliardo, L. F., Ruyechan, M. C., Lee, N. A., Lee, J. J., & Appleton, J. A. (2014). Eosinophil-derived IL-10 supports chronic nematode infection. Journal of Immunology, 193(8), 4178-4187. https://doi.org/10.4049/jimmunol.1400852

Eosinophil-derived IL-10 supports chronic nematode infection. / Huang, Lu; Gebreselassie, Nebiat G.; Gagliardo, Lucille F.; Ruyechan, Maura C.; Lee, Nancy A; Lee, James J.; Appleton, Judith A.

In: Journal of Immunology, Vol. 193, No. 8, 15.10.2014, p. 4178-4187.

Research output: Contribution to journalArticle

Huang, L, Gebreselassie, NG, Gagliardo, LF, Ruyechan, MC, Lee, NA, Lee, JJ & Appleton, JA 2014, 'Eosinophil-derived IL-10 supports chronic nematode infection', Journal of Immunology, vol. 193, no. 8, pp. 4178-4187. https://doi.org/10.4049/jimmunol.1400852
Huang L, Gebreselassie NG, Gagliardo LF, Ruyechan MC, Lee NA, Lee JJ et al. Eosinophil-derived IL-10 supports chronic nematode infection. Journal of Immunology. 2014 Oct 15;193(8):4178-4187. https://doi.org/10.4049/jimmunol.1400852
Huang, Lu ; Gebreselassie, Nebiat G. ; Gagliardo, Lucille F. ; Ruyechan, Maura C. ; Lee, Nancy A ; Lee, James J. ; Appleton, Judith A. / Eosinophil-derived IL-10 supports chronic nematode infection. In: Journal of Immunology. 2014 ; Vol. 193, No. 8. pp. 4178-4187.
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