Environmental tobacco smoke exposure in women with lung cancer

Mariza De Andrade, Jon Owen Ebbert, J. A. Wampfler, D. L. Miller, Randolph Stuart Marks, G. A. Croghan, Aminah Jatoi, E. E. Finke, T. A. Sellers, Ping Yang

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Background: Investigations on environmental tobacco smoke (ETS) exposure that include source intensity, childhood exposure, and association with histologic subtypes among never smoking lung cancer cases are limited. We report the patterns of ETS exposure history in a clinical cohort of women with newly diagnosed lung cancer. Methods: From 1997 to 2001, 810 women with lung cancer were interviewed to obtain data including the source, intensity, and duration of ETS exposure. In this descriptive study, relationships between smoking history, ETS exposure, and lung cancer histologic subtypes were analyzed. Results: Among the 810 patients, 773 (95.4%) reported personal smoking or ETS exposure including 170 of 207 (82%) never smokers. Among the never smokers with a history of ETS exposure, the mean years of exposure were 27 from a smoking spouse, 19 from parents, and 15 from co-workers. For each major subtype of lung cancer (adenocarcinoma, squamous cell, unclassified non-small cell lung cancer, small cell, or carcinoids) among never smokers, 75-100% of patients had ETS exposure. Trends for adenocarcinoma, squamous, and small cell carcinoma are statistically significant using the Cochran-Armitage Test for Trend (P<0.001) among never smokers without ETS exposure, never smokers with ETS exposure, former smokers, and current smokers. Conclusions: Over 95% of women with lung cancer in our study were exposed to tobacco smoke through a personal smoking history or ETS. The cumulative amount of tobacco smoke exposure may be significantly underestimated if only personal smoking history is considered. Our results add to the public health implications of exposure to tobacco smoke and highlight the importance of eliminating tobacco smoking in public and private settings.

Original languageEnglish (US)
Pages (from-to)127-134
Number of pages8
JournalLung Cancer
Volume43
Issue number2
DOIs
StatePublished - Feb 2004

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Smoke
Tobacco
Lung Neoplasms
Smoking
History
Small Cell Carcinoma
Information Storage and Retrieval
Carcinoid Tumor
Spouses
Non-Small Cell Lung Carcinoma
Squamous Cell Carcinoma
Adenocarcinoma
Public Health
Parents
Epithelial Cells

Keywords

  • Environmental tobacco smoke
  • Lung cancer
  • Women

ASJC Scopus subject areas

  • Oncology

Cite this

Environmental tobacco smoke exposure in women with lung cancer. / De Andrade, Mariza; Ebbert, Jon Owen; Wampfler, J. A.; Miller, D. L.; Marks, Randolph Stuart; Croghan, G. A.; Jatoi, Aminah; Finke, E. E.; Sellers, T. A.; Yang, Ping.

In: Lung Cancer, Vol. 43, No. 2, 02.2004, p. 127-134.

Research output: Contribution to journalArticle

De Andrade, Mariza ; Ebbert, Jon Owen ; Wampfler, J. A. ; Miller, D. L. ; Marks, Randolph Stuart ; Croghan, G. A. ; Jatoi, Aminah ; Finke, E. E. ; Sellers, T. A. ; Yang, Ping. / Environmental tobacco smoke exposure in women with lung cancer. In: Lung Cancer. 2004 ; Vol. 43, No. 2. pp. 127-134.
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abstract = "Background: Investigations on environmental tobacco smoke (ETS) exposure that include source intensity, childhood exposure, and association with histologic subtypes among never smoking lung cancer cases are limited. We report the patterns of ETS exposure history in a clinical cohort of women with newly diagnosed lung cancer. Methods: From 1997 to 2001, 810 women with lung cancer were interviewed to obtain data including the source, intensity, and duration of ETS exposure. In this descriptive study, relationships between smoking history, ETS exposure, and lung cancer histologic subtypes were analyzed. Results: Among the 810 patients, 773 (95.4{\%}) reported personal smoking or ETS exposure including 170 of 207 (82{\%}) never smokers. Among the never smokers with a history of ETS exposure, the mean years of exposure were 27 from a smoking spouse, 19 from parents, and 15 from co-workers. For each major subtype of lung cancer (adenocarcinoma, squamous cell, unclassified non-small cell lung cancer, small cell, or carcinoids) among never smokers, 75-100{\%} of patients had ETS exposure. Trends for adenocarcinoma, squamous, and small cell carcinoma are statistically significant using the Cochran-Armitage Test for Trend (P<0.001) among never smokers without ETS exposure, never smokers with ETS exposure, former smokers, and current smokers. Conclusions: Over 95{\%} of women with lung cancer in our study were exposed to tobacco smoke through a personal smoking history or ETS. The cumulative amount of tobacco smoke exposure may be significantly underestimated if only personal smoking history is considered. Our results add to the public health implications of exposure to tobacco smoke and highlight the importance of eliminating tobacco smoking in public and private settings.",
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AU - Marks, Randolph Stuart

AU - Croghan, G. A.

AU - Jatoi, Aminah

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AB - Background: Investigations on environmental tobacco smoke (ETS) exposure that include source intensity, childhood exposure, and association with histologic subtypes among never smoking lung cancer cases are limited. We report the patterns of ETS exposure history in a clinical cohort of women with newly diagnosed lung cancer. Methods: From 1997 to 2001, 810 women with lung cancer were interviewed to obtain data including the source, intensity, and duration of ETS exposure. In this descriptive study, relationships between smoking history, ETS exposure, and lung cancer histologic subtypes were analyzed. Results: Among the 810 patients, 773 (95.4%) reported personal smoking or ETS exposure including 170 of 207 (82%) never smokers. Among the never smokers with a history of ETS exposure, the mean years of exposure were 27 from a smoking spouse, 19 from parents, and 15 from co-workers. For each major subtype of lung cancer (adenocarcinoma, squamous cell, unclassified non-small cell lung cancer, small cell, or carcinoids) among never smokers, 75-100% of patients had ETS exposure. Trends for adenocarcinoma, squamous, and small cell carcinoma are statistically significant using the Cochran-Armitage Test for Trend (P<0.001) among never smokers without ETS exposure, never smokers with ETS exposure, former smokers, and current smokers. Conclusions: Over 95% of women with lung cancer in our study were exposed to tobacco smoke through a personal smoking history or ETS. The cumulative amount of tobacco smoke exposure may be significantly underestimated if only personal smoking history is considered. Our results add to the public health implications of exposure to tobacco smoke and highlight the importance of eliminating tobacco smoking in public and private settings.

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