TY - JOUR
T1 - ENvironmental Dynamics Underlying Responsive Extreme Survivors (ENDURES) of Glioblastoma
T2 - A Multi-disciplinary Team-based, Multifactorial Analytical Approach
AU - Johnston, Sandra K.
AU - Whitmire, Paula
AU - Massey, Susan Christine
AU - Kumthekar, Priya
AU - Porter, Alyx B.
AU - Raghunand, Natarajan
AU - Gonzalez-Cuyar, Luis F.
AU - Mrugala, Maciej M.
AU - Hawkins-Daarud, Andrea
AU - Jackson, Pamela R.
AU - Hu, Leland S.
AU - Sarkaria, Jann N.
AU - Wang, Lei
AU - Gatenby, Robert A.
AU - Egan, Kathleen M.
AU - Canoll, Peter
AU - Swanson, Kristin R.
N1 - Publisher Copyright:
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2018/11/4
Y1 - 2018/11/4
N2 - Although glioblastoma is a fatal primary brain cancer with a short median survival of 15 months, a small number of patients survive more than 5 years after diagnosis; they are known as extreme survivors (ES). Due to their rarity, very little is known about what differentiates these outliers from other glioblastoma patients. For the purpose of identifying unknown drivers of extreme survivorship in glioblastoma, we developed the ENDURES consortium (ENvironmental Dynamics Underlying Responsive Extreme Survivors of glioblastoma). This consortium is a multicenter collaborative network of investigators focused on the integration of multiple types of clinical data and the creation of patient-specific models of tumor growth informed by radiographic and histological parameters. Leveraging our combined resources, the goals of the ENDURES consortium are two-fold: (1) to build a curated, searchable, multilayered repository housing clinical and outcome data on a large cohort of ES patients with glioblastoma and (2) to leverage the ENDURES repository for new insights on tumor behavior and novel targets for prolonging survival for all glioblastoma patients. In this article, we review the available literature and discuss what is already known about ES. We then describe the creation of our consortium and some of our preliminary results. Funding This review was financially supported by a grant from the James S. McDonnell Foundation Conflicts of Interest The authors have declared that no conflicts of interest exist. Authorship Conceptualized consortium: LW, RG, KME, PC, and KRS. Built consortium: SKJ, PK, NR, JS, KME, PC, and KRS. Wrote the manuscript: SKJ, PW, SCM, PK, AP, and KME. Reviewed and edited the manuscript: LFGC, MMM, AHD, PRJ, and LSH. Contributed to writing, provided feedback, and approved of final manuscript: All authors. Link to website for ENDURES http://mathematicalneurooncology.org/?page_id=2125
AB - Although glioblastoma is a fatal primary brain cancer with a short median survival of 15 months, a small number of patients survive more than 5 years after diagnosis; they are known as extreme survivors (ES). Due to their rarity, very little is known about what differentiates these outliers from other glioblastoma patients. For the purpose of identifying unknown drivers of extreme survivorship in glioblastoma, we developed the ENDURES consortium (ENvironmental Dynamics Underlying Responsive Extreme Survivors of glioblastoma). This consortium is a multicenter collaborative network of investigators focused on the integration of multiple types of clinical data and the creation of patient-specific models of tumor growth informed by radiographic and histological parameters. Leveraging our combined resources, the goals of the ENDURES consortium are two-fold: (1) to build a curated, searchable, multilayered repository housing clinical and outcome data on a large cohort of ES patients with glioblastoma and (2) to leverage the ENDURES repository for new insights on tumor behavior and novel targets for prolonging survival for all glioblastoma patients. In this article, we review the available literature and discuss what is already known about ES. We then describe the creation of our consortium and some of our preliminary results. Funding This review was financially supported by a grant from the James S. McDonnell Foundation Conflicts of Interest The authors have declared that no conflicts of interest exist. Authorship Conceptualized consortium: LW, RG, KME, PC, and KRS. Built consortium: SKJ, PK, NR, JS, KME, PC, and KRS. Wrote the manuscript: SKJ, PW, SCM, PK, AP, and KME. Reviewed and edited the manuscript: LFGC, MMM, AHD, PRJ, and LSH. Contributed to writing, provided feedback, and approved of final manuscript: All authors. Link to website for ENDURES http://mathematicalneurooncology.org/?page_id=2125
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U2 - 10.1101/461236
DO - 10.1101/461236
M3 - Article
AN - SCOPUS:85095628270
JO - American Journal of Physiology - Renal Fluid and Electrolyte Physiology
JF - American Journal of Physiology - Renal Fluid and Electrolyte Physiology
SN - 1931-857X
ER -