Enterohepatic physiology of 1,25-dihydroxyvitamin D3 metabolites in normal man

Russell H. Wiesner, Rajiv Kumar, Ego Seeman, V. L.W. Go

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Within 6 hr of the intravenous administration of radiolabeled 1,25(OH)2D3 to five normal vitamin D-replete human subjects, 15.6% of the injected dose appeared in bile as polar metabolites of 1,25(OH)2D3. Of the injected dose, 27% and 7.5% appeared in the feces and urine, respectively, at 24 hr. In another two subjects, biliary radioactivity was sampled at two jejunal sites separated by a distance of 40 cm; a 24.8% decrease in radioactivity over this segment of bowel was noted. These data demonstrate that products of 1,25(OH)2D3 are excreted in normal human bile. Furthermore, these products are reabsorbed as such or as free 1,25(OH)2D3 in the intestine and re-excreted as polar products in bile. Our data suggest that there is an enterohepatic circulation of the products of 1,25(OH)2D3 in normal man.

Original languageEnglish (US)
Pages (from-to)1094-1100
Number of pages7
JournalThe Journal of Laboratory and Clinical Medicine
Volume96
Issue number6
StatePublished - Dec 1980

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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