Abstract
The goals of this review are to summarize some of the novel observations on the genetic and molecular basis of enteric nervous system disorders, with particular emphasis on the relevance of these observations to the practicising neurogastroenterologist. In the last two decades, there has been a greater understanding of genetic loci involved in congenital forms of pseudo-obstruction and Hirschsprung's disease; and the contribution of endothelins and nuclear transcription factors to the development of the enteric nervous system. In addition, clarification of the molecules involved in the activation of the peristaltic reflex, the disorders of the interstitial cells of Cajal, the clinical manifestations of mitochondrial cytopathies affecting the gut, and the application of neurotrophic factors for disorders of colonic function have impacted on practical management of patients with gut dysmotility.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 277-295 |
| Number of pages | 19 |
| Journal | Neurogastroenterology and Motility |
| Volume | 13 |
| Issue number | 4 |
| DOIs | |
| State | Published - 2001 |
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Keywords
- Constipation
- Hirschsprung's
- Megacolon
- Neurotrophins
- Pseudo-obstruction
- Tyrosine kinase
ASJC Scopus subject areas
- Physiology
- Gastroenterology
- Neuroscience(all)
Cite this
Enteric nervous system disorders : Genetic and molecular insights for the neurogastroenterologist. / Camilleri, Michael.
In: Neurogastroenterology and Motility, Vol. 13, No. 4, 2001, p. 277-295.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Enteric nervous system disorders
T2 - Genetic and molecular insights for the neurogastroenterologist
AU - Camilleri, Michael
PY - 2001
Y1 - 2001
N2 - The goals of this review are to summarize some of the novel observations on the genetic and molecular basis of enteric nervous system disorders, with particular emphasis on the relevance of these observations to the practicising neurogastroenterologist. In the last two decades, there has been a greater understanding of genetic loci involved in congenital forms of pseudo-obstruction and Hirschsprung's disease; and the contribution of endothelins and nuclear transcription factors to the development of the enteric nervous system. In addition, clarification of the molecules involved in the activation of the peristaltic reflex, the disorders of the interstitial cells of Cajal, the clinical manifestations of mitochondrial cytopathies affecting the gut, and the application of neurotrophic factors for disorders of colonic function have impacted on practical management of patients with gut dysmotility.
AB - The goals of this review are to summarize some of the novel observations on the genetic and molecular basis of enteric nervous system disorders, with particular emphasis on the relevance of these observations to the practicising neurogastroenterologist. In the last two decades, there has been a greater understanding of genetic loci involved in congenital forms of pseudo-obstruction and Hirschsprung's disease; and the contribution of endothelins and nuclear transcription factors to the development of the enteric nervous system. In addition, clarification of the molecules involved in the activation of the peristaltic reflex, the disorders of the interstitial cells of Cajal, the clinical manifestations of mitochondrial cytopathies affecting the gut, and the application of neurotrophic factors for disorders of colonic function have impacted on practical management of patients with gut dysmotility.
KW - Constipation
KW - Hirschsprung's
KW - Megacolon
KW - Neurotrophins
KW - Pseudo-obstruction
KW - Tyrosine kinase
UR - http://www.scopus.com/inward/record.url?scp=0034799579&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034799579&partnerID=8YFLogxK
U2 - 10.1046/j.1365-2982.2001.00277.x
DO - 10.1046/j.1365-2982.2001.00277.x
M3 - Article
C2 - 11576388
AN - SCOPUS:0034799579
VL - 13
SP - 277
EP - 295
JO - Neurogastroenterology and Motility
JF - Neurogastroenterology and Motility
SN - 1350-1925
IS - 4
ER -