Enteric Autoantibodies and Gut Motility Disorders

Purna Kashyap; Gianrico Farrugia

doi:10.1016/j.gtc.2008.02.005

Enteric Autoantibodies and Gut Motility Disorders

Purna Kashyap, Gianrico Farrugia

Research output: Contribution to journal › Review article › peer-review

35 Scopus citations

Abstract

Increasing evidence suggests that a subset of gastrointestinal motility disorders is associated with the presence of circulating antibodies. These antibodies are directed against various molecular targets, the best known being anti-neuronal nuclear antibody (ANNA-1 or anti-Hu) associated with paraneoplastic motility disorders. There is also evidence that the presence of distinct autoantibody profiles is associated with non-paraneoplastic motility disorders. This review focuses on the types of antibodies associated with gastrointestinal motility disorders and the significance of these antibodies. Algorithms are suggested for the work-up and treatment of patients with circulating antibodies associated with gastrointestinal motility disorders.

Original language	English (US)
Pages (from-to)	397-410
Number of pages	14
Journal	Gastroenterology Clinics of North America
Volume	37
Issue number	2
DOIs	https://doi.org/10.1016/j.gtc.2008.02.005
State	Published - Jun 2008

ASJC Scopus subject areas

Gastroenterology

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10.1016/j.gtc.2008.02.005

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abstract = "Increasing evidence suggests that a subset of gastrointestinal motility disorders is associated with the presence of circulating antibodies. These antibodies are directed against various molecular targets, the best known being anti-neuronal nuclear antibody (ANNA-1 or anti-Hu) associated with paraneoplastic motility disorders. There is also evidence that the presence of distinct autoantibody profiles is associated with non-paraneoplastic motility disorders. This review focuses on the types of antibodies associated with gastrointestinal motility disorders and the significance of these antibodies. Algorithms are suggested for the work-up and treatment of patients with circulating antibodies associated with gastrointestinal motility disorders.",

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AB - Increasing evidence suggests that a subset of gastrointestinal motility disorders is associated with the presence of circulating antibodies. These antibodies are directed against various molecular targets, the best known being anti-neuronal nuclear antibody (ANNA-1 or anti-Hu) associated with paraneoplastic motility disorders. There is also evidence that the presence of distinct autoantibody profiles is associated with non-paraneoplastic motility disorders. This review focuses on the types of antibodies associated with gastrointestinal motility disorders and the significance of these antibodies. Algorithms are suggested for the work-up and treatment of patients with circulating antibodies associated with gastrointestinal motility disorders.

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Enteric Autoantibodies and Gut Motility Disorders

Abstract

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