Abstract
To determine the pharmacokinetic properties of ciprofloxacin in the critically ill, we studied seven mechanically ventilated patients with pneumonia during enteral feedings. Subjects received ciprofloxacin 750 mg every 12 h via nasogastric tube and serial serum drug concentrations were measured after the first and fourth dose. After the initial dose, the maximum serum concentration ranged from 1.24-3.06 mg/L, and the area under the time curve from 0-12 h ranged from 3.2-19.65 mg.h/L. Similar levels were noted after dose four. Gastrointestinal absorption of ciprofloxacin in tube fed critically ill patients was decreased, but well above MIC values for many pathogenic bacteria.
Original language | English (US) |
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Pages (from-to) | 871-876 |
Number of pages | 6 |
Journal | Journal of Antimicrobial Chemotherapy |
Volume | 38 |
Issue number | 5 |
DOIs | |
State | Published - 1996 |
ASJC Scopus subject areas
- Pharmacology
- Microbiology (medical)
- Infectious Diseases
- Pharmacology (medical)