Enteral glutamine supplementation impairs intestinal blood flow in rats

Paul J. Matheson, Brady T. Harris, Ryan T Hurt, E. Rasheid Zakaria, R. Neal Garrison

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Clinical studies have shown that enteral immune-enhancing diets (IEDs) containing l-glutamine decrease septic complications and length of stay in some patient populations. Animal studies suggest IED benefits might include augmented gut blood flow. We hypothesized that enteral glutamine supplementation modulates gastrointestinal blood flow. Methods: Blood flow was measured in male Sprague-Dawley rats via the colorimetric microsphere technique at baseline, 60, and 120 minutes. Four groups were studied: (1) control diet (CD) + enteral glutamine; (2) CD + enteral glycine; (3) CD + enteral saline; and (4) CD + intravenous glutamine. Results: There were no differences in blood pressure or heart rate in any group. Group 1 blood flow was decreased at 120 minutes compared with controls (groups 2 and 3) in small intestine, colon, spleen, and pancreas, whereas the intravenous glutamine group (group 4) had no effect on blood flow. Conclusions: Enteral glutamine supplementation (as in IEDs) appears to impair gastrointestinal blood flow. Because glutamine provides energy directly to active enterocytes, enteral glutamine availability might diminish metabolic stimuli of absorptive hyperemia. This finding might partially explain the benefits observed with parenteral versus enteral glutamine supplementation in clinical studies (such as bone-marrow-transplant patients).

Original languageEnglish (US)
Pages (from-to)293-299
Number of pages7
JournalAmerican Journal of Surgery
Volume196
Issue number2
DOIs
StatePublished - Aug 2008
Externally publishedYes

Fingerprint

Glutamine
Small Intestine
Diet
Enterocytes
Hyperemia
Blood Group Antigens
Microspheres
Glycine
Sprague Dawley Rats
Pancreas
Length of Stay
Colon
Spleen
Heart Rate
Bone Marrow
Blood Pressure
Transplants
Control Groups
Population

Keywords

  • Blood flow
  • Immunonutrition
  • l-glutamine
  • Microspheres
  • Total parenteral nutrition

ASJC Scopus subject areas

  • Surgery

Cite this

Enteral glutamine supplementation impairs intestinal blood flow in rats. / Matheson, Paul J.; Harris, Brady T.; Hurt, Ryan T; Zakaria, E. Rasheid; Garrison, R. Neal.

In: American Journal of Surgery, Vol. 196, No. 2, 08.2008, p. 293-299.

Research output: Contribution to journalArticle

Matheson, Paul J. ; Harris, Brady T. ; Hurt, Ryan T ; Zakaria, E. Rasheid ; Garrison, R. Neal. / Enteral glutamine supplementation impairs intestinal blood flow in rats. In: American Journal of Surgery. 2008 ; Vol. 196, No. 2. pp. 293-299.
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