“Enjoy glass of wine before eating:” a randomized trial to test the orexigenic effects of this advice in advanced cancer patients

Aminah Jatoi, Rui Qin, Daniel Satele, Shaker Dakhil, Pankaj Kumar, David B. Johnson, Sachdev P. Thomas, Philip J. Stella, Jose Castillo, Min Li, Martin Fernandez-Zapico

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Background: Because the extant literature suggests wine increases appetite, this study sought to determine whether this effect could be observed in advanced cancer patients with appetite loss. Methods: Advanced cancer patients with self-reported loss of appetite were randomly assigned to white wine with ≤15 % alcohol content twice a day for 3–4 weeks versus a nutritional supplement, such as Boost® or Ensure®. Patients assigned to wine were encouraged to also take a nutritional supplement, whereas patients assigned to the nutritional supplement arm were told to abstain completely from alcohol. Patient-reported outcomes were captured with a validated questionnaire to assess the primary endpoint of appetite improvement. Results: A total of 141 patients (118 evaluable) were enrolled. Twenty-eight patients (48 %) in the wine arm reported an improvement in appetite at some point during the treatment period, whereas 22 patients (37 %) assigned to the nutritional supplement arm also reported improvement (p = 0.35). Other appetite-related questions and questionnaire items showed no statistically significant differences between treatment arms. In both arms, approximately 9 % of patients achieved weight stability (p = 0.98); median survival was not statistically different. Both interventions were well tolerated. Conclusion: As prescribed in this trial, wine does not improve appetite or weight in advanced cancer patients.

Original languageEnglish (US)
Pages (from-to)3739-3746
Number of pages8
JournalSupportive Care in Cancer
Volume24
Issue number9
DOIs
StatePublished - Sep 1 2016

Keywords

  • Anorexia
  • Appetite
  • Cancer
  • Hunger
  • Weight loss

ASJC Scopus subject areas

  • Oncology

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