Abstract
Purpose of Review: This review summarizes literature pertaining to the dawning field of therapeutic targeting of mitochondria in hypertension and discusses the potential of these interventions to ameliorate hypertension-induced organ damage. Recent Findings: In recent years, mitochondrial dysfunction has been reported as an important contributor to the pathogenesis of hypertension-related renal, cardiac, and vascular disease. This in turn prompted development of novel mitochondria-targeted compounds, some of which have shown promising efficacy in experimental studies and safety in clinical trials. In addition, drugs that do not directly target mitochondria have shown remarkable benefits in preserving these organelles in experimental hypertension. Summary: Enhancing mitochondrial health is emerging as a novel feasible approach to treat hypertension. Future perspectives include mechanistic experimental studies to establish a cause-effect relationship between mitochondrial dysfunction and hypertension and further clinical trials to confirm the reno-, cardio-, and vasculo-protective properties of these compounds in hypertension.
| Original language | English (US) |
|---|---|
| Article number | 89 |
| Journal | Current Hypertension Reports |
| Volume | 20 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 1 2018 |
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Keywords
- Blood pressure
- Heart
- Hypertension
- Kidney
- Mitochondria
- Vasculature
ASJC Scopus subject areas
- Internal Medicine
Cite this
Enhancing Mitochondrial Health to Treat Hypertension. / Eirin, Alfonso; Lerman, Amir; Lerman, Lilach O.
In: Current Hypertension Reports, Vol. 20, No. 10, 89, 01.10.2018.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Enhancing Mitochondrial Health to Treat Hypertension
AU - Eirin, Alfonso
AU - Lerman, Amir
AU - Lerman, Lilach O
PY - 2018/10/1
Y1 - 2018/10/1
N2 - Purpose of Review: This review summarizes literature pertaining to the dawning field of therapeutic targeting of mitochondria in hypertension and discusses the potential of these interventions to ameliorate hypertension-induced organ damage. Recent Findings: In recent years, mitochondrial dysfunction has been reported as an important contributor to the pathogenesis of hypertension-related renal, cardiac, and vascular disease. This in turn prompted development of novel mitochondria-targeted compounds, some of which have shown promising efficacy in experimental studies and safety in clinical trials. In addition, drugs that do not directly target mitochondria have shown remarkable benefits in preserving these organelles in experimental hypertension. Summary: Enhancing mitochondrial health is emerging as a novel feasible approach to treat hypertension. Future perspectives include mechanistic experimental studies to establish a cause-effect relationship between mitochondrial dysfunction and hypertension and further clinical trials to confirm the reno-, cardio-, and vasculo-protective properties of these compounds in hypertension.
AB - Purpose of Review: This review summarizes literature pertaining to the dawning field of therapeutic targeting of mitochondria in hypertension and discusses the potential of these interventions to ameliorate hypertension-induced organ damage. Recent Findings: In recent years, mitochondrial dysfunction has been reported as an important contributor to the pathogenesis of hypertension-related renal, cardiac, and vascular disease. This in turn prompted development of novel mitochondria-targeted compounds, some of which have shown promising efficacy in experimental studies and safety in clinical trials. In addition, drugs that do not directly target mitochondria have shown remarkable benefits in preserving these organelles in experimental hypertension. Summary: Enhancing mitochondrial health is emerging as a novel feasible approach to treat hypertension. Future perspectives include mechanistic experimental studies to establish a cause-effect relationship between mitochondrial dysfunction and hypertension and further clinical trials to confirm the reno-, cardio-, and vasculo-protective properties of these compounds in hypertension.
KW - Blood pressure
KW - Heart
KW - Hypertension
KW - Kidney
KW - Mitochondria
KW - Vasculature
UR - http://www.scopus.com/inward/record.url?scp=85051732750&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85051732750&partnerID=8YFLogxK
U2 - 10.1007/s11906-018-0889-4
DO - 10.1007/s11906-018-0889-4
M3 - Review article
VL - 20
JO - Current Hypertension Reports
JF - Current Hypertension Reports
SN - 1522-6417
IS - 10
M1 - 89
ER -