Enhancement of Learning and Memory by Elevating Brain Magnesium

Inna Slutsky, Nashat Abumaria, LongJun Wu, Chao Huang, Ling Zhang, Bo Li, Xiang Zhao, Arvind Govindarajan, Ming Gao Zhao, Min Zhuo, Susumu Tonegawa, Guosong Liu

Research output: Contribution to journalArticle

159 Citations (Scopus)

Abstract

Learning and memory are fundamental brain functions affected by dietary and environmental factors. Here, we show that increasing brain magnesium using a newly developed magnesium compound (magnesium-L-threonate, MgT) leads to the enhancement of learning abilities, working memory, and short- and long-term memory in rats. The pattern completion ability was also improved in aged rats. MgT-treated rats had higher density of synaptophysin-/synaptobrevin-positive puncta in DG and CA1 subregions of hippocampus that were correlated with memory improvement. Functionally, magnesium increased the number of functional presynaptic release sites, while it reduced their release probability. The resultant synaptic reconfiguration enabled selective enhancement of synaptic transmission for burst inputs. Coupled with concurrent upregulation of NR2B-containing NMDA receptors and its downstream signaling, synaptic plasticity induced by correlated inputs was enhanced. Our findings suggest that an increase in brain magnesium enhances both short-term synaptic facilitation and long-term potentiation and improves learning and memory functions.

Original languageEnglish (US)
Pages (from-to)165-177
Number of pages13
JournalNeuron
Volume65
Issue number2
DOIs
StatePublished - Jan 28 2010
Externally publishedYes

Fingerprint

Magnesium
Aptitude
Learning
Magnesium Compounds
Brain
R-SNARE Proteins
Synaptophysin
Neuronal Plasticity
Long-Term Memory
Long-Term Potentiation
Short-Term Memory
Synaptic Transmission
Hippocampus
Up-Regulation
threonic acid
NR2B NMDA receptor

Keywords

  • HUMDISEASE
  • MOLNEURO
  • SIGNALING

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Slutsky, I., Abumaria, N., Wu, L., Huang, C., Zhang, L., Li, B., ... Liu, G. (2010). Enhancement of Learning and Memory by Elevating Brain Magnesium. Neuron, 65(2), 165-177. https://doi.org/10.1016/j.neuron.2009.12.026

Enhancement of Learning and Memory by Elevating Brain Magnesium. / Slutsky, Inna; Abumaria, Nashat; Wu, LongJun; Huang, Chao; Zhang, Ling; Li, Bo; Zhao, Xiang; Govindarajan, Arvind; Zhao, Ming Gao; Zhuo, Min; Tonegawa, Susumu; Liu, Guosong.

In: Neuron, Vol. 65, No. 2, 28.01.2010, p. 165-177.

Research output: Contribution to journalArticle

Slutsky, I, Abumaria, N, Wu, L, Huang, C, Zhang, L, Li, B, Zhao, X, Govindarajan, A, Zhao, MG, Zhuo, M, Tonegawa, S & Liu, G 2010, 'Enhancement of Learning and Memory by Elevating Brain Magnesium', Neuron, vol. 65, no. 2, pp. 165-177. https://doi.org/10.1016/j.neuron.2009.12.026
Slutsky I, Abumaria N, Wu L, Huang C, Zhang L, Li B et al. Enhancement of Learning and Memory by Elevating Brain Magnesium. Neuron. 2010 Jan 28;65(2):165-177. https://doi.org/10.1016/j.neuron.2009.12.026
Slutsky, Inna ; Abumaria, Nashat ; Wu, LongJun ; Huang, Chao ; Zhang, Ling ; Li, Bo ; Zhao, Xiang ; Govindarajan, Arvind ; Zhao, Ming Gao ; Zhuo, Min ; Tonegawa, Susumu ; Liu, Guosong. / Enhancement of Learning and Memory by Elevating Brain Magnesium. In: Neuron. 2010 ; Vol. 65, No. 2. pp. 165-177.
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