Enhancement of human lymphocyte natural killing function by non-opioid fragments of β-endorphin

Neil Kay, John E. Morley, Jan M. van Ree

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Opioid peptides have been shown to enhance peripheral blood lymphocyte natural killer (NK) cell function. In this study, we report that certain non-opioid fragments of beta-endorphin (2-16, 2-17, and 6-17) enhance NK activity with peak dose responses seen at 10-12 to 10-15 concentrations. This effect can be inhibited by naloxone. We conclude that non-opioid fragments of beta-endorphin are more potent than either beta- or gamma-endorphin in enhancing human lymphocyte NK activity.

Original languageEnglish (US)
Pages (from-to)1083-1087
Number of pages5
JournalLife Sciences
Volume40
Issue number11
DOIs
StatePublished - Mar 16 1987

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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