Enhancement of human lymphocyte natural killing function by non-opioid fragments of β-endorphin

Neil Kay; John E. Morley; Jan M. van Ree

doi:10.1016/0024-3205(87)90571-6

Enhancement of human lymphocyte natural killing function by non-opioid fragments of β-endorphin

Neil Kay, John E. Morley, Jan M. van Ree

Hematology

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Opioid peptides have been shown to enhance peripheral blood lymphocyte natural killer (NK) cell function. In this study, we report that certain non-opioid fragments of beta-endorphin (2-16, 2-17, and 6-17) enhance NK activity with peak dose responses seen at 10^-12 to 10^-15 concentrations. This effect can be inhibited by naloxone. We conclude that non-opioid fragments of beta-endorphin are more potent than either beta- or gamma-endorphin in enhancing human lymphocyte NK activity.

Original language	English (US)
Pages (from-to)	1083-1087
Number of pages	5
Journal	Life Sciences
Volume	40
Issue number	11
DOIs	https://doi.org/10.1016/0024-3205(87)90571-6
State	Published - Mar 16 1987

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

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10.1016/0024-3205(87)90571-6

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title = "Enhancement of human lymphocyte natural killing function by non-opioid fragments of β-endorphin",

abstract = "Opioid peptides have been shown to enhance peripheral blood lymphocyte natural killer (NK) cell function. In this study, we report that certain non-opioid fragments of beta-endorphin (2-16, 2-17, and 6-17) enhance NK activity with peak dose responses seen at 10-12 to 10-15 concentrations. This effect can be inhibited by naloxone. We conclude that non-opioid fragments of beta-endorphin are more potent than either beta- or gamma-endorphin in enhancing human lymphocyte NK activity.",

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AU - Kay, Neil

AU - Morley, John E.

AU - van Ree, Jan M.

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Y1 - 1987/3/16

N2 - Opioid peptides have been shown to enhance peripheral blood lymphocyte natural killer (NK) cell function. In this study, we report that certain non-opioid fragments of beta-endorphin (2-16, 2-17, and 6-17) enhance NK activity with peak dose responses seen at 10-12 to 10-15 concentrations. This effect can be inhibited by naloxone. We conclude that non-opioid fragments of beta-endorphin are more potent than either beta- or gamma-endorphin in enhancing human lymphocyte NK activity.

AB - Opioid peptides have been shown to enhance peripheral blood lymphocyte natural killer (NK) cell function. In this study, we report that certain non-opioid fragments of beta-endorphin (2-16, 2-17, and 6-17) enhance NK activity with peak dose responses seen at 10-12 to 10-15 concentrations. This effect can be inhibited by naloxone. We conclude that non-opioid fragments of beta-endorphin are more potent than either beta- or gamma-endorphin in enhancing human lymphocyte NK activity.

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Enhancement of human lymphocyte natural killing function by non-opioid fragments of β-endorphin

Abstract

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