Enhanced pain-induced activity of pain-processing regions in a case-control study of episodic migraine

Todd J Schwedt, Catherine D. Chong, Chia Chun Chiang, Leslie Baxter, Bradley L. Schlaggar, David William Dodick

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Objective: The objective of this study was to identify brain regions having aberrant pain-induced activation in migraineurs, thereby gaining insight into particular aspects of pain processing that are atypical in migraineurs.

Methods: Functional magnetic resonance imaging assessed whole brain responses to painful heat in 24 adult episodic migraineurs who were at least 48 hours pain free and 27 healthy controls. Regions differentially activated in migraineurs compared to controls were identified. Activation intensities in these regions were correlated with headache frequency, number of migraine years, and time to next migraine attack.

Results: Migraineurs had greater pain-induced activation of lentiform nucleus, fusiform gyrus, subthalamic nucleus, hippocampus, middle cingulate cortex, premotor cortex, somatosensory cortex, and dorsolateral prefrontal cortex, and less activation in precentral gyrus and superior temporal gyrus. There were significant correlations between activation strength and headache frequency for middle cingulate (r= 0.627, p= 0.001), right dorsolateral prefrontal cortex (r= 0.568, p= 0.004), left fusiform gyrus (r= 0.487, p= 0.016), left precentral gyrus (r= 0.415, p= 0.044), and left hippocampus (r= 0.404, p= 0.050) and with number of migraine years for left fusiform gyrus (r= 0.425, p= 0.038). There were no significant correlations between activation strength and time to next migraine attack.

Conclusions: The majority of regions with enhanced pain-induced activation in headache-free migraineurs participate in cognitive aspects of pain perception such as attending to pain and pain memory. Enhanced cognitive pain processing by migraineurs might reflect cerebral hypersensitivity related to high expectations and hypervigilance for pain.

Original languageEnglish (US)
Pages (from-to)947-958
Number of pages12
JournalCephalalgia
Volume34
Issue number12
DOIs
StatePublished - Oct 27 2014

Fingerprint

Migraine Disorders
Case-Control Studies
Pain
Temporal Lobe
Headache
Frontal Lobe
Prefrontal Cortex
Hippocampus
Corpus Striatum
Subthalamic Nucleus
Pain Perception
Somatosensory Cortex
Gyrus Cinguli
Motor Cortex
Brain
Hypersensitivity
Anxiety
Hot Temperature
Magnetic Resonance Imaging

Keywords

  • cognitive pain processing
  • functional magnetic resonance imaging
  • headache
  • Migraine
  • pain

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Enhanced pain-induced activity of pain-processing regions in a case-control study of episodic migraine. / Schwedt, Todd J; Chong, Catherine D.; Chiang, Chia Chun; Baxter, Leslie; Schlaggar, Bradley L.; Dodick, David William.

In: Cephalalgia, Vol. 34, No. 12, 27.10.2014, p. 947-958.

Research output: Contribution to journalArticle

Schwedt, Todd J ; Chong, Catherine D. ; Chiang, Chia Chun ; Baxter, Leslie ; Schlaggar, Bradley L. ; Dodick, David William. / Enhanced pain-induced activity of pain-processing regions in a case-control study of episodic migraine. In: Cephalalgia. 2014 ; Vol. 34, No. 12. pp. 947-958.
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AB - Objective: The objective of this study was to identify brain regions having aberrant pain-induced activation in migraineurs, thereby gaining insight into particular aspects of pain processing that are atypical in migraineurs.Methods: Functional magnetic resonance imaging assessed whole brain responses to painful heat in 24 adult episodic migraineurs who were at least 48 hours pain free and 27 healthy controls. Regions differentially activated in migraineurs compared to controls were identified. Activation intensities in these regions were correlated with headache frequency, number of migraine years, and time to next migraine attack.Results: Migraineurs had greater pain-induced activation of lentiform nucleus, fusiform gyrus, subthalamic nucleus, hippocampus, middle cingulate cortex, premotor cortex, somatosensory cortex, and dorsolateral prefrontal cortex, and less activation in precentral gyrus and superior temporal gyrus. There were significant correlations between activation strength and headache frequency for middle cingulate (r= 0.627, p= 0.001), right dorsolateral prefrontal cortex (r= 0.568, p= 0.004), left fusiform gyrus (r= 0.487, p= 0.016), left precentral gyrus (r= 0.415, p= 0.044), and left hippocampus (r= 0.404, p= 0.050) and with number of migraine years for left fusiform gyrus (r= 0.425, p= 0.038). There were no significant correlations between activation strength and time to next migraine attack.Conclusions: The majority of regions with enhanced pain-induced activation in headache-free migraineurs participate in cognitive aspects of pain perception such as attending to pain and pain memory. Enhanced cognitive pain processing by migraineurs might reflect cerebral hypersensitivity related to high expectations and hypervigilance for pain.

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