Abstract
The efficiency of viruses in cancer therapy is enhanced by proteins that mediate the fusion of infected cells with their neighbors. It was reported that replication-competent adenovirus particles can spread between nuclei within fusion-generated syncytia. To assess this conjecture, we generated fusogenic adenoviruses that express a balanced ratio of the F and H glycoproteins of measles virus. The viruses displayed enhanced cytotoxicity but largely unchanged replication efficiencies compared to a nonfusogenic virus. Most notably, the virus genomes did not spread through fusion-generated multinuclear cells. Hence, adenovirus replication in syncytia remains largely restricted to initially transduced nuclei.
Original language | English (US) |
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Pages (from-to) | 1911-1917 |
Number of pages | 7 |
Journal | Journal of virology |
Volume | 79 |
Issue number | 3 |
DOIs | |
State | Published - Feb 2005 |
ASJC Scopus subject areas
- Microbiology
- Immunology
- Insect Science
- Virology