Enhanced cell-mediated protection against fatal Escherichia coli septicemia induced by treatment with recombinant IL-2

J. Goronzy, C. Weyland, J. Quan, C. G. Fathman, P. O'Hanley

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Administration of rIL-2 to BALB/c mice induces a rapid, cell-mediated response that is sufficient to protect mice from a lethal i.p. dose of Escherichia coli. Mice were protected from septic death if IL-2 was administered i.p. within 1 h after the bacterial challenge. Optimal protection was provided by treating the lethally challenged mice with rIL-2 at 1 and 5 h or 1, 5, and 10 h after the bacterial challenge and was dose-dependent (≥ 5.0 x 105 U/kg). Furthermore, treatment of mice with anti-IL-2R antibody abolished the protective effect induced by rIL-2 administration. These data suggest that the rIL-2-induced protection against septic death in mice is mediated by a cell type expressing a functional IL-2R. One potentially important therapeutic application of rIL-2 may be to modulate the course of sepsis once the host has been exposed to potentially lethal microbial pathogens.

Original languageEnglish (US)
Pages (from-to)1134-1138
Number of pages5
JournalJournal of Immunology
Volume142
Issue number4
StatePublished - 1989

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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