Enhanced angiogenesis and unfavorable remodeling in injured porcine coronary artery lesions: Effects of local basic fibroblast growth factor delivery

Michael E. Staab, Robert D. Simari, Sanjay S. Srivatsa, David Hasdai, Vincent J. Pompili, David R. Holmes, Robert S. Schwartz

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

There is interest in the role of growth factors in the genesis of arterial remodeling. We studied local administration of basic fibroblast growth factor (bFGF) to coronary lesions to determine whether there is a difference in remodeling and whether neovascularization could be induced in such stenoses and distal myocardium. Pigs were randomized to balloon infusion of either saline or bFGF at each thermally injured arterial site. After the animals were killed, their internal elastic lamina, neointima, and lumen areas were measured. Capillaries were counted in the arteries and myocardium. There was a greater loss of lumen and internal elastic lamina in the bFGF group. The neointima, media, and myocardium in the bFGF treated arteries had statistically more capillaries. This study showed that local intracoronary bFGF, at a dose that results in arterial luminal revascularization in injured segments, adversely affects arterial remodeling. Thus, the angiogenic response to exogenous bFGF may be offset by concomitant shrinkage of injured arterial segments.

Original languageEnglish (US)
Pages (from-to)753-760
Number of pages8
JournalAngiology
Volume48
Issue number9
DOIs
StatePublished - Sep 1997

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ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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