Engineering of hetero-functional gold nanorods for the in vivo molecular targeting of breast cancer cells

Mohammad Eghtedari; Anton V. Liopo; John A. Copland; Alexander A. Oraevsky; Massoud Motamed

doi:10.1021/nl802915q

Engineering of hetero-functional gold nanorods for the in vivo molecular targeting of breast cancer cells

Mohammad Eghtedari, Anton V. Liopo, John A. Copland, Alexander A. Oraevsky, Massoud Motamed

Cancer Biology

Research output: Contribution to journal › Article › peer-review

195 Scopus citations

Abstract

A novel technique is described to functionalize gold nanorods (GNRs) allowing for in vivo targeting of breast cancer tumors grown in athymic nude mice. GNRs were functionalized by covalent attachment of Herceptin (HER), a monoclonal antibody that enables molecular recognition of breast cancer cells expressing highly specific tumor associated antigens, and poly(ethylene glycol) (PEG) which obscures particles against the reticuloendothelial system in the body. The stability and functionality of fabricated particles (Her-PEG GNRs) were demonstrated in vitro in the presence of blood and then in vivo in nude mice model for breast cancer. The results demonstrate successful tumor accumulation of functionalized gold nanorods within HER2/neu overexpressing breast tumors in tumor-bearing nude mice and support the notions that GNRs can be used for molecular imaging of tumor.

Original language	English (US)
Pages (from-to)	287-291
Number of pages	5
Journal	Nano Letters
Volume	9
Issue number	1
DOIs	https://doi.org/10.1021/nl802915q
State	Published - Jan 2009

ASJC Scopus subject areas

Bioengineering
Chemistry(all)
Materials Science(all)
Condensed Matter Physics
Mechanical Engineering

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abstract = "A novel technique is described to functionalize gold nanorods (GNRs) allowing for in vivo targeting of breast cancer tumors grown in athymic nude mice. GNRs were functionalized by covalent attachment of Herceptin (HER), a monoclonal antibody that enables molecular recognition of breast cancer cells expressing highly specific tumor associated antigens, and poly(ethylene glycol) (PEG) which obscures particles against the reticuloendothelial system in the body. The stability and functionality of fabricated particles (Her-PEG GNRs) were demonstrated in vitro in the presence of blood and then in vivo in nude mice model for breast cancer. The results demonstrate successful tumor accumulation of functionalized gold nanorods within HER2/neu overexpressing breast tumors in tumor-bearing nude mice and support the notions that GNRs can be used for molecular imaging of tumor.",

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AU - Eghtedari, Mohammad

AU - Liopo, Anton V.

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AU - Oraevsky, Alexander A.

AU - Motamed, Massoud

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Engineering of hetero-functional gold nanorods for the in vivo molecular targeting of breast cancer cells

Abstract

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