Abstract
Dendritic cells are pivotal regulators of immune reactivity and immune tolerance. The observation that dendritic cells can recruit naive T-cells has invigorated cancer immunology and stimulated clinical trials of dendritic cells in immunotherapy. However, variables inherent in preparation and use of dendritic cell grafts remain to be tested. Here we discuss the role of ex vivo dendritic cell processing for in vivo antigen presentation in clinical trials. As an example of the complexity in a clinical trial of dendritic cell vaccines, we present our ongoing trial in immunotherapy of chronic myelogenous leukemia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 428-435 |
| Number of pages | 8 |
| Journal | Croatian Medical Journal |
| Volume | 42 |
| Issue number | 4 |
| State | Published - 2001 |
Keywords
- Antigen-presenting cells
- Cancer vaccines
- Cells fusion
- Dendritic cells
- Immunotherapy
- T lymphocytes
ASJC Scopus subject areas
- General Medicine