Energy metabolism in the acquisition and maintenance of stemness

Research output: Contribution to journalReview article

38 Citations (Scopus)

Abstract

Energy metabolism is traditionally considered a reactive homeostatic system addressing stage-specific cellular energy needs. There is however growing appreciation of metabolic pathways in the active control of vital cell functions. Case in point, the stem cell lifecycle - from maintenance and acquisition of stemness to lineage commitment and specification - is increasingly recognized as a metabolism-dependent process. Indeed, metabolic reprogramming is an early contributor to the orchestrated departure from or reacquisition of stemness. Recent advances in metabolomics have helped decipher the identity and dynamics of metabolic fluxes implicated in fueling cell fate choices by regulating the epigenetic and transcriptional identity of a cell. Metabolic cues, internal and/or external to the stem cell niche, facilitate progenitor pool restitution, long-term tissue renewal or ensure adoption of cytoprotective behavior. Convergence of energy metabolism with stem cell fate regulation opens a new avenue in understanding primordial developmental biology principles with future applications in regenerative medicine practice.

Original languageEnglish (US)
Pages (from-to)68-75
Number of pages8
JournalSeminars in Cell and Developmental Biology
Volume52
DOIs
StatePublished - Apr 1 2016

Fingerprint

Energy Metabolism
Maintenance
Stem Cells
Stem Cell Niche
Developmental Biology
Regenerative Medicine
Metabolomics
Metabolic Networks and Pathways
Epigenomics
Cues

Keywords

  • Embryonic stem cells
  • Glycolysis
  • Hematopoietic stem cells
  • Induced pluripotent stem cells
  • Metabolic remodeling
  • Mitochondria
  • Nuclear reprograming
  • Oxidative metabolism

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

Energy metabolism in the acquisition and maintenance of stemness. / Folmes, Clifford; Terzic, Andre.

In: Seminars in Cell and Developmental Biology, Vol. 52, 01.04.2016, p. 68-75.

Research output: Contribution to journalReview article

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