Energy expenditure, sex, and endogenous fuel availability in humans

Søoren Nielsen, ZengKui Guo, Jeanine B. Albu, Samuel Klein, Peter C. O'Brien, Michael Dennis Jensen

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

Adipose tissue lipolysis supplies circulating FFAs, which largely meet lipid fuel needs; however, excess FFAs, can contribute to the adverse health consequences of obesity. Because "normal" FFA release has not been well defined, average (mean of 4 days) basal FFA release and its potential regulation factors were measured in 50 lean and obese adults (25 women). Resting energy expenditure (REE), but not body composition, predicted most of the interindividual variation in FFA release. There was a significant, positive linear relationship between palmitate release and REE; however, women released approximately 40% more FFA than men relative to REE. Neither plasma palmitate concentrations nor respiratory quotient by indirect calorimetry differed between men and women. Glucose release rates were not different in men and women whether related to REE or fat free mass. These findings indicate that nonoxidative FFA clearance is greater in women than in men. This could be an advantage at times of increased fuel needs. We conclude that "normal" adipose tissue lipolysis is different in men and women and that the fuel export role of adipose tissue in obesity will need to be reassessed.

Original languageEnglish (US)
Pages (from-to)981-988
Number of pages8
JournalJournal of Clinical Investigation
Volume111
Issue number7
DOIs
StatePublished - Apr 2003

Fingerprint

Energy Metabolism
Adipose Tissue
Palmitates
Lipolysis
Obesity
Indirect Calorimetry
Body Composition
Fats
Lipids
Glucose
Health

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Energy expenditure, sex, and endogenous fuel availability in humans. / Nielsen, Søoren; Guo, ZengKui; Albu, Jeanine B.; Klein, Samuel; O'Brien, Peter C.; Jensen, Michael Dennis.

In: Journal of Clinical Investigation, Vol. 111, No. 7, 04.2003, p. 981-988.

Research output: Contribution to journalArticle

Nielsen, Søoren ; Guo, ZengKui ; Albu, Jeanine B. ; Klein, Samuel ; O'Brien, Peter C. ; Jensen, Michael Dennis. / Energy expenditure, sex, and endogenous fuel availability in humans. In: Journal of Clinical Investigation. 2003 ; Vol. 111, No. 7. pp. 981-988.
@article{aaecd9b82b184865a2a728c19808b049,
title = "Energy expenditure, sex, and endogenous fuel availability in humans",
abstract = "Adipose tissue lipolysis supplies circulating FFAs, which largely meet lipid fuel needs; however, excess FFAs, can contribute to the adverse health consequences of obesity. Because {"}normal{"} FFA release has not been well defined, average (mean of 4 days) basal FFA release and its potential regulation factors were measured in 50 lean and obese adults (25 women). Resting energy expenditure (REE), but not body composition, predicted most of the interindividual variation in FFA release. There was a significant, positive linear relationship between palmitate release and REE; however, women released approximately 40{\%} more FFA than men relative to REE. Neither plasma palmitate concentrations nor respiratory quotient by indirect calorimetry differed between men and women. Glucose release rates were not different in men and women whether related to REE or fat free mass. These findings indicate that nonoxidative FFA clearance is greater in women than in men. This could be an advantage at times of increased fuel needs. We conclude that {"}normal{"} adipose tissue lipolysis is different in men and women and that the fuel export role of adipose tissue in obesity will need to be reassessed.",
author = "S{\o}oren Nielsen and ZengKui Guo and Albu, {Jeanine B.} and Samuel Klein and O'Brien, {Peter C.} and Jensen, {Michael Dennis}",
year = "2003",
month = "4",
doi = "10.1172/JCI200316253",
language = "English (US)",
volume = "111",
pages = "981--988",
journal = "Journal of Clinical Investigation",
issn = "0021-9738",
publisher = "The American Society for Clinical Investigation",
number = "7",

}

TY - JOUR

T1 - Energy expenditure, sex, and endogenous fuel availability in humans

AU - Nielsen, Søoren

AU - Guo, ZengKui

AU - Albu, Jeanine B.

AU - Klein, Samuel

AU - O'Brien, Peter C.

AU - Jensen, Michael Dennis

PY - 2003/4

Y1 - 2003/4

N2 - Adipose tissue lipolysis supplies circulating FFAs, which largely meet lipid fuel needs; however, excess FFAs, can contribute to the adverse health consequences of obesity. Because "normal" FFA release has not been well defined, average (mean of 4 days) basal FFA release and its potential regulation factors were measured in 50 lean and obese adults (25 women). Resting energy expenditure (REE), but not body composition, predicted most of the interindividual variation in FFA release. There was a significant, positive linear relationship between palmitate release and REE; however, women released approximately 40% more FFA than men relative to REE. Neither plasma palmitate concentrations nor respiratory quotient by indirect calorimetry differed between men and women. Glucose release rates were not different in men and women whether related to REE or fat free mass. These findings indicate that nonoxidative FFA clearance is greater in women than in men. This could be an advantage at times of increased fuel needs. We conclude that "normal" adipose tissue lipolysis is different in men and women and that the fuel export role of adipose tissue in obesity will need to be reassessed.

AB - Adipose tissue lipolysis supplies circulating FFAs, which largely meet lipid fuel needs; however, excess FFAs, can contribute to the adverse health consequences of obesity. Because "normal" FFA release has not been well defined, average (mean of 4 days) basal FFA release and its potential regulation factors were measured in 50 lean and obese adults (25 women). Resting energy expenditure (REE), but not body composition, predicted most of the interindividual variation in FFA release. There was a significant, positive linear relationship between palmitate release and REE; however, women released approximately 40% more FFA than men relative to REE. Neither plasma palmitate concentrations nor respiratory quotient by indirect calorimetry differed between men and women. Glucose release rates were not different in men and women whether related to REE or fat free mass. These findings indicate that nonoxidative FFA clearance is greater in women than in men. This could be an advantage at times of increased fuel needs. We conclude that "normal" adipose tissue lipolysis is different in men and women and that the fuel export role of adipose tissue in obesity will need to be reassessed.

UR - http://www.scopus.com/inward/record.url?scp=0037380644&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037380644&partnerID=8YFLogxK

U2 - 10.1172/JCI200316253

DO - 10.1172/JCI200316253

M3 - Article

VL - 111

SP - 981

EP - 988

JO - Journal of Clinical Investigation

JF - Journal of Clinical Investigation

SN - 0021-9738

IS - 7

ER -