Energy expenditure, insulin, and VLDL-triglyceride production in humans

Lars C. Gormsen, Michael Dennis Jensen, Ole Schmitz, Niels Møller, Jens S. Christiansen, Søren Nielsen

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Hypertriglyceridemia is considered a cardiovascular risk factor in diabetic and nondiabetic subjects. In this study, we aimed to determine potential regulators of very low density lipoprotein-triglyceride (TG) production. VLDL-TG kinetics were measured in 13 men and 12 women {body mass index [mean (range)]: 24.8 (20.2-35.6) kg/m2}. VLDL-TG production was assessed from the plasma decay of a bolus injection of ex vivo labeled VLDL particles ([1- 14C]triolein-VLDL-TG). Similar VLDL-TG production (mmol/min) was found in men and women. VLDL-TG production was not significantly correlated with palmitate flux ([9,10-3H]palmitate) (r = 0.09, P = 0.67) or palmitate concentration (r = 20.29, P = 0.2) but was correlated significantly with fasting insulin concentration (r = 0.46, P < 0.05) and resting energy expenditure (REE) (r = 0.45, P < 0.05). The latter correlation improved when adjusted for sex. The best multivariate model with VLDL-TG production as the dependent variable and REE, body composition, hormones, and substrate levels as independent variables included fasting insulin (P = 0.02) and REE (P = 0.02) (r2 = 0.32, P < 0.001). We conclude that VLDL kinetics are similar in men and women and that REE and plasma insulin are significant independent predictors of VLDL-TG production. FFA availability and body fat distribution are unrelated to VLDL production. We suggest that REE plays a greater role in VLDL-TG production than previously anticipated. REE and insulin should be taken into account when VLDL-TG production comparisons between groups are made.

Original languageEnglish (US)
Pages (from-to)2325-2332
Number of pages8
JournalJournal of Lipid Research
Volume47
Issue number10
DOIs
StatePublished - Oct 2006

Fingerprint

Energy Metabolism
Insulin
Palmitates
Fasting
very low density lipoprotein triglyceride
Triolein
Body Fat Distribution
Plasmas
Kinetics
Hypertriglyceridemia
Body Composition
Body Mass Index
Fats
Availability
Hormones
Fluxes
Injections
Substrates
Chemical analysis

Keywords

  • Free fatty acids
  • Lipoproteins
  • Very low density lipoprotein

ASJC Scopus subject areas

  • Endocrinology

Cite this

Gormsen, L. C., Jensen, M. D., Schmitz, O., Møller, N., Christiansen, J. S., & Nielsen, S. (2006). Energy expenditure, insulin, and VLDL-triglyceride production in humans. Journal of Lipid Research, 47(10), 2325-2332. https://doi.org/10.1194/jlr.M600175-JLR200

Energy expenditure, insulin, and VLDL-triglyceride production in humans. / Gormsen, Lars C.; Jensen, Michael Dennis; Schmitz, Ole; Møller, Niels; Christiansen, Jens S.; Nielsen, Søren.

In: Journal of Lipid Research, Vol. 47, No. 10, 10.2006, p. 2325-2332.

Research output: Contribution to journalArticle

Gormsen, LC, Jensen, MD, Schmitz, O, Møller, N, Christiansen, JS & Nielsen, S 2006, 'Energy expenditure, insulin, and VLDL-triglyceride production in humans', Journal of Lipid Research, vol. 47, no. 10, pp. 2325-2332. https://doi.org/10.1194/jlr.M600175-JLR200
Gormsen, Lars C. ; Jensen, Michael Dennis ; Schmitz, Ole ; Møller, Niels ; Christiansen, Jens S. ; Nielsen, Søren. / Energy expenditure, insulin, and VLDL-triglyceride production in humans. In: Journal of Lipid Research. 2006 ; Vol. 47, No. 10. pp. 2325-2332.
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