Endovascular brain intervention and mapping in a dog experimental model using magnetically-guided micro-catheter technology

Tomas Kara, Pavel Leinveber, Michal Vlasin, Pavel Jurak, Miroslav Novak, Zdenek Novak, Jan Chrastina, Krzysztof Czechowicz, Milos Belehrad, Samuel J. Asirvatham

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Aim. Despite the substantial progress that has been achieved in interventional cardiology and cardiac electrophysiology, endovascular intervention for the diagnosis and treatment of central nervous system (CNS) disorders such as stroke, epilepsy and CNS malignancy is still limited, particularly due to highly tortuous nature of the cerebral arterial and venous system. Existing interventional devices and techniques enable only limited and complicated access especially into intra-cerebral vessels. The aim of this study was to develop a micro-catheter magnetically-guided technology specifically designed for endovascular intervention and mapping in deep CNS vascular structures. Methods. Mapping of electrical brain activity was performed via the venous system on an animal dog model with the support of the NIOBE II system. Results. A novel micro-catheter specially designed for endovascular interventions in the CNS, with the support of the NIOBE II technology, was able to reach safely deep intra-cerebral venous structures and map the electrical activity there. Such structures are not currently accessible using standard catheters. Conclusion. This is the first study demonstrating successful use of a new micro-catheter in combination with NIOBE II technology for endovascular intervention in the brain.

Original languageEnglish (US)
Pages (from-to)221-226
Number of pages6
JournalBiomedical Papers
Volume158
Issue number2
DOIs
StatePublished - 2014

Keywords

  • Central nervous system
  • Magnetically-guided endovascular interventions
  • Mapping
  • NIOBE

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Kara, T., Leinveber, P., Vlasin, M., Jurak, P., Novak, M., Novak, Z., Chrastina, J., Czechowicz, K., Belehrad, M., & Asirvatham, S. J. (2014). Endovascular brain intervention and mapping in a dog experimental model using magnetically-guided micro-catheter technology. Biomedical Papers, 158(2), 221-226. https://doi.org/10.5507/bp.2012.076