Endotherapy for and tailored approaches to treating GERD, and refractory GERD

G. Richard Locke, John Horwhat, Hiroshi Mashimo, Edoardo Savarino, Patrizia Zentilin, Vincenzo Savarino, Frank Zerbib, Steven P. Armbruster, Roy K. Wong, Fouad Moawad

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

This paper presents commentaries on how endoluminal antireflux procedures compare to laparoscopic fundoplication; new endoscopic procedures being studied to treat refractory gastroesophageal reflux disease (GERD); the new Stretta; the relationship between obesity and proton pump inhibitor (PPI) resistance; data concerning acid hypersensitivity and sensory receptors (vallinoid, TRPV1) causing refractory GERD; whether microscopic esophagitis is relevant in determining symptoms of non-erosive reflux disease (NERD); how concomitant functional gastrointestinal disorders affect the PPI response in NERD; the evidence that a functional esophagus is associated with inflammatory bowel syndrome (IBS); the role of GABA agonists in the treatment of refractory GERD; the role of biofeedback and antidepressants in refractory GERD; and endoluminal fundoplication using the EsophyX device.

Original languageEnglish (US)
Pages (from-to)166-186
Number of pages21
JournalAnnals of the New York Academy of Sciences
Volume1300
Issue number1
DOIs
StatePublished - Oct 2013

Fingerprint

Gastroesophageal Reflux
Refractory materials
Fundoplication
Proton Pump Inhibitors
GABA Agonists
Esophagitis
Gastrointestinal Diseases
Sensory Receptor Cells
Biofeedback
Antidepressive Agents
Esophagus
Hypersensitivity
Obesity
Equipment and Supplies
Acids
Therapeutics

Keywords

  • Antidepressants
  • Functional heartburn
  • GABA agonists
  • IBS
  • NERD
  • PPI
  • TRPV1

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Locke, G. R., Horwhat, J., Mashimo, H., Savarino, E., Zentilin, P., Savarino, V., ... Moawad, F. (2013). Endotherapy for and tailored approaches to treating GERD, and refractory GERD. Annals of the New York Academy of Sciences, 1300(1), 166-186. https://doi.org/10.1111/nyas.12240

Endotherapy for and tailored approaches to treating GERD, and refractory GERD. / Locke, G. Richard; Horwhat, John; Mashimo, Hiroshi; Savarino, Edoardo; Zentilin, Patrizia; Savarino, Vincenzo; Zerbib, Frank; Armbruster, Steven P.; Wong, Roy K.; Moawad, Fouad.

In: Annals of the New York Academy of Sciences, Vol. 1300, No. 1, 10.2013, p. 166-186.

Research output: Contribution to journalArticle

Locke, GR, Horwhat, J, Mashimo, H, Savarino, E, Zentilin, P, Savarino, V, Zerbib, F, Armbruster, SP, Wong, RK & Moawad, F 2013, 'Endotherapy for and tailored approaches to treating GERD, and refractory GERD', Annals of the New York Academy of Sciences, vol. 1300, no. 1, pp. 166-186. https://doi.org/10.1111/nyas.12240
Locke GR, Horwhat J, Mashimo H, Savarino E, Zentilin P, Savarino V et al. Endotherapy for and tailored approaches to treating GERD, and refractory GERD. Annals of the New York Academy of Sciences. 2013 Oct;1300(1):166-186. https://doi.org/10.1111/nyas.12240
Locke, G. Richard ; Horwhat, John ; Mashimo, Hiroshi ; Savarino, Edoardo ; Zentilin, Patrizia ; Savarino, Vincenzo ; Zerbib, Frank ; Armbruster, Steven P. ; Wong, Roy K. ; Moawad, Fouad. / Endotherapy for and tailored approaches to treating GERD, and refractory GERD. In: Annals of the New York Academy of Sciences. 2013 ; Vol. 1300, No. 1. pp. 166-186.
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