Endotherapy for and tailored approaches to treating GERD, and refractory GERD

G. Richard Locke; John Horwhat; Hiroshi Mashimo; Edoardo Savarino; Patrizia Zentilin; Vincenzo Savarino; Frank Zerbib; Steven P. Armbruster; Roy K. Wong; Fouad Moawad

doi:10.1111/nyas.12240

Endotherapy for and tailored approaches to treating GERD, and refractory GERD

G. Richard Locke, John Horwhat, Hiroshi Mashimo, Edoardo Savarino, Patrizia Zentilin, Vincenzo Savarino, Frank Zerbib, Steven P. Armbruster, Roy K. Wong, Fouad Moawad

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

This paper presents commentaries on how endoluminal antireflux procedures compare to laparoscopic fundoplication; new endoscopic procedures being studied to treat refractory gastroesophageal reflux disease (GERD); the new Stretta; the relationship between obesity and proton pump inhibitor (PPI) resistance; data concerning acid hypersensitivity and sensory receptors (vallinoid, TRPV1) causing refractory GERD; whether microscopic esophagitis is relevant in determining symptoms of non-erosive reflux disease (NERD); how concomitant functional gastrointestinal disorders affect the PPI response in NERD; the evidence that a functional esophagus is associated with inflammatory bowel syndrome (IBS); the role of GABA agonists in the treatment of refractory GERD; the role of biofeedback and antidepressants in refractory GERD; and endoluminal fundoplication using the EsophyX device.

Original language	English (US)
Pages (from-to)	166-186
Number of pages	21
Journal	Annals of the New York Academy of Sciences
Volume	1300
Issue number	1
DOIs	https://doi.org/10.1111/nyas.12240
State	Published - Oct 2013

Keywords

Antidepressants
Functional heartburn
GABA agonists
IBS
NERD
PPI
TRPV1

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
History and Philosophy of Science

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10.1111/nyas.12240

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title = "Endotherapy for and tailored approaches to treating GERD, and refractory GERD",

abstract = "This paper presents commentaries on how endoluminal antireflux procedures compare to laparoscopic fundoplication; new endoscopic procedures being studied to treat refractory gastroesophageal reflux disease (GERD); the new Stretta; the relationship between obesity and proton pump inhibitor (PPI) resistance; data concerning acid hypersensitivity and sensory receptors (vallinoid, TRPV1) causing refractory GERD; whether microscopic esophagitis is relevant in determining symptoms of non-erosive reflux disease (NERD); how concomitant functional gastrointestinal disorders affect the PPI response in NERD; the evidence that a functional esophagus is associated with inflammatory bowel syndrome (IBS); the role of GABA agonists in the treatment of refractory GERD; the role of biofeedback and antidepressants in refractory GERD; and endoluminal fundoplication using the EsophyX device.",

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author = "Locke, {G. Richard} and John Horwhat and Hiroshi Mashimo and Edoardo Savarino and Patrizia Zentilin and Vincenzo Savarino and Frank Zerbib and Armbruster, {Steven P.} and Wong, {Roy K.} and Fouad Moawad",

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AU - Horwhat, John

AU - Mashimo, Hiroshi

AU - Savarino, Edoardo

AU - Zentilin, Patrizia

AU - Savarino, Vincenzo

AU - Zerbib, Frank

AU - Armbruster, Steven P.

AU - Wong, Roy K.

AU - Moawad, Fouad

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N2 - This paper presents commentaries on how endoluminal antireflux procedures compare to laparoscopic fundoplication; new endoscopic procedures being studied to treat refractory gastroesophageal reflux disease (GERD); the new Stretta; the relationship between obesity and proton pump inhibitor (PPI) resistance; data concerning acid hypersensitivity and sensory receptors (vallinoid, TRPV1) causing refractory GERD; whether microscopic esophagitis is relevant in determining symptoms of non-erosive reflux disease (NERD); how concomitant functional gastrointestinal disorders affect the PPI response in NERD; the evidence that a functional esophagus is associated with inflammatory bowel syndrome (IBS); the role of GABA agonists in the treatment of refractory GERD; the role of biofeedback and antidepressants in refractory GERD; and endoluminal fundoplication using the EsophyX device.

AB - This paper presents commentaries on how endoluminal antireflux procedures compare to laparoscopic fundoplication; new endoscopic procedures being studied to treat refractory gastroesophageal reflux disease (GERD); the new Stretta; the relationship between obesity and proton pump inhibitor (PPI) resistance; data concerning acid hypersensitivity and sensory receptors (vallinoid, TRPV1) causing refractory GERD; whether microscopic esophagitis is relevant in determining symptoms of non-erosive reflux disease (NERD); how concomitant functional gastrointestinal disorders affect the PPI response in NERD; the evidence that a functional esophagus is associated with inflammatory bowel syndrome (IBS); the role of GABA agonists in the treatment of refractory GERD; the role of biofeedback and antidepressants in refractory GERD; and endoluminal fundoplication using the EsophyX device.

KW - Antidepressants

KW - Functional heartburn

KW - GABA agonists

KW - IBS

KW - NERD

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KW - TRPV1

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Endotherapy for and tailored approaches to treating GERD, and refractory GERD

Abstract

Keywords

ASJC Scopus subject areas

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