Endothelium-dependent responses in autogenous femoral veins grafted into the arterial circulation of the dog

V. M. Miller, M. M. Reigel, L. H. Hollier, P. M. Vanhoutte

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

Endothelium-dependent responses differ in arteries and veins of the dog. Experiments were performed to determine whether chronic grafting of veins into the arterial circulation would alter the endothelium-dependent responses of the veins. Segments of femoral veins were grafted to the femoral artery of the dog. 6 wk after surgery the venous grafts were removed from the dog, cut into rings, and suspended in organ chambers for isometric tension recording. In some rings the endothelial cells were removed. Acetylcholine and α2-adrenergic agonists did not cause endothelium-dependent relaxations in venous grafts. The calcium ionophore (A23187) initiated such relaxations which were not mediated by prostanoids. Endothelium-dependent relaxations were also observed in venous grafts to ADP, thrombin, and arachidonic acid. In segments of graft where myo-intimal hyperplasia was prominent, relaxations to ADP, thrombin, and A23187 were blunted and in some segments contractions were observed. These results demonstrate the ability of the endothelium of venous grafts to initiate changes in tone of the smooth muscle.

Original languageEnglish (US)
Pages (from-to)1350-1357
Number of pages8
JournalJournal of Clinical Investigation
Volume80
Issue number5
DOIs
StatePublished - 1987

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Endothelium-dependent responses in autogenous femoral veins grafted into the arterial circulation of the dog'. Together they form a unique fingerprint.

  • Cite this