Endothelium-dependent relaxations to histamine in the rat common carotid, renal and cranial mesenteric artery

M. K. Krstić, Radica M. Stepanović, S. K. Krstic, Z. S. Katušić

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The effect of histamine on the isolated rat common carotid, renal and cranial mesenteric arteries was examined. Histamine (10-8 - 10-4 m) caused concentration-dependent relaxations of the arteries during contractions induced with phenylephrine (10-8 - 10-7 m). Removal of the vascular endothelium inhibited the histamine-induced relaxations. Pyrilamine (6 × 10-6 m), but not metiamide (10-6 m), abolished the relaxant effect of histamine. Moreover, pyrilamine (6 × 10-6 m) did not affect endothelium-dependent relaxations of the arteries produced with acetylcholine. These results indicate that histamine causes endothelium-dependent relaxations of the rat peripheral large conduit arteries, which appeared to be mediated via H1-histaminergic receptors.

Original languageEnglish (US)
Pages (from-to)197-200
Number of pages4
JournalArchives of Physiology and Biochemistry
Volume96
Issue number3
DOIs
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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