TY - JOUR
T1 - Endothelium-dependent relaxations to histamine in the rat common carotid, renal and cranial mesenteric artery
AU - Krstić, M. K.
AU - Stepanović, Radica M.
AU - Krstic, S. K.
AU - Katušić, Z. S.
N1 - Funding Information:
Acknowledgment. - This work was supported by the Union of the Scientific Medical Institutions of Serbia (Grant No. 231).
PY - 1988
Y1 - 1988
N2 - The effect of histamine on the isolated rat common carotid, renal and cranial mesenteric arteries was examined. Histamine (10-8 - 10-4 m) caused concentration-dependent relaxations of the arteries during contractions induced with phenylephrine (10-8 - 10-7 m). Removal of the vascular endothelium inhibited the histamine-induced relaxations. Pyrilamine (6 × 10-6 m), but not metiamide (10-6 m), abolished the relaxant effect of histamine. Moreover, pyrilamine (6 × 10-6 m) did not affect endothelium-dependent relaxations of the arteries produced with acetylcholine. These results indicate that histamine causes endothelium-dependent relaxations of the rat peripheral large conduit arteries, which appeared to be mediated via H1-histaminergic receptors.
AB - The effect of histamine on the isolated rat common carotid, renal and cranial mesenteric arteries was examined. Histamine (10-8 - 10-4 m) caused concentration-dependent relaxations of the arteries during contractions induced with phenylephrine (10-8 - 10-7 m). Removal of the vascular endothelium inhibited the histamine-induced relaxations. Pyrilamine (6 × 10-6 m), but not metiamide (10-6 m), abolished the relaxant effect of histamine. Moreover, pyrilamine (6 × 10-6 m) did not affect endothelium-dependent relaxations of the arteries produced with acetylcholine. These results indicate that histamine causes endothelium-dependent relaxations of the rat peripheral large conduit arteries, which appeared to be mediated via H1-histaminergic receptors.
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U2 - 10.3109/13813458809075944
DO - 10.3109/13813458809075944
M3 - Article
C2 - 2474280
AN - SCOPUS:0024212973
SN - 1381-3455
VL - 96
SP - 197
EP - 200
JO - Archives of Physiology and Biochemistry
JF - Archives of Physiology and Biochemistry
IS - 3
ER -