Endothelium-dependent relaxations to histamine in the rat common carotid, renal and cranial mesenteric artery

M. K. Krstić, Radica M. Stepanović, S. K. Krstic, Zvonimir S Katusic

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The effect of histamine on the isolated rat common carotid, renal and cranial mesenteric arteries was examined. Histamine (10-8 - 10-4 m) caused concentration-dependent relaxations of the arteries during contractions induced with phenylephrine (10-8 - 10-7 m). Removal of the vascular endothelium inhibited the histamine-induced relaxations. Pyrilamine (6 × 10-6 m), but not metiamide (10-6 m), abolished the relaxant effect of histamine. Moreover, pyrilamine (6 × 10-6 m) did not affect endothelium-dependent relaxations of the arteries produced with acetylcholine. These results indicate that histamine causes endothelium-dependent relaxations of the rat peripheral large conduit arteries, which appeared to be mediated via H1-histaminergic receptors.

Original languageEnglish (US)
Pages (from-to)197-200
Number of pages4
JournalArchives of Physiology and Biochemistry
Volume96
Issue number3
DOIs
StatePublished - 1988
Externally publishedYes

Fingerprint

Mesenteric Arteries
Histamine
Endothelium
Rats
Kidney
Pyrilamine
Arteries
Metiamide
Histamine H1 Receptors
Vascular Endothelium
Phenylephrine
Acetylcholine

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Biochemistry

Cite this

Endothelium-dependent relaxations to histamine in the rat common carotid, renal and cranial mesenteric artery. / Krstić, M. K.; Stepanović, Radica M.; Krstic, S. K.; Katusic, Zvonimir S.

In: Archives of Physiology and Biochemistry, Vol. 96, No. 3, 1988, p. 197-200.

Research output: Contribution to journalArticle

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