Endothelin in thoracic inferior vena caval constriction model of heart failure

R. D. Underwood, L. L. Aarhus, D. M. Heublein, John C Jr. Burnett

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Recent studies have found endothelin-1 (ET), a potent vasoconstrictor of endothelial cell origin, is increased in congestive heart failure (CHF) in plasma and correlates with increased atrial pressures. Additionally, it has been shown that, despite increased circulating ET concentrations in CHF, a decreased responsiveness to exogenous ET infusion exists in an experimental model of CHF induced by rapid pacing. The present study was designed to determine whether plasma ET would be increased in a model of low cardiac output congestive failure without elevated atrial pressures produced by thoracic inferior vena caval constriction (TIVCC). In addition, we sought to determine whether this model of low cardiac output would show a full vasoconstrictive response to exogenous ET infusion and whether atrial natriuretic factor (ANF) infused acutely to achieve pathophysiological concentrations would modulate the systemic and renal hemodynamic responses to exogenous ET. Dogs were studied in the anesthetized state at 8-9 days after the TIVCC or sham operation. Baseline ET levels were significantly increased in the TIVCC dogs (n = 14) compared with sham operated dogs (n = 6; 41.4 ± 7.1 vs. 17.9 ± 1.5 pg/ml, respectively; P < 0.05). With exogenous ET infusion (5 ng · kg-1 · min-1), an intact systemic and renal vasoconstrictor response in the TIVCC dogs was observed. ANF prevented the systemic vascular and arterial pressure responses to ET. However, the potent renal vasoconstricting action of ET was not prevented by ANF. These studies suggest that ET may play an important role in maintaining blood pressure in the setting of low cardiac output. Additionally, they suggest ANF has an important counterregulatory role in the control of systemic hemodynamics.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume263
Issue number3 32-3
StatePublished - 1992

Fingerprint

Venae Cavae
Endothelins
Endothelin-1
Constriction
Thorax
Heart Failure
Atrial Natriuretic Factor
Low Cardiac Output
Dogs
Atrial Pressure
Vasoconstrictor Agents
Kidney
Hemodynamics
Blood Vessels
Arterial Pressure
Theoretical Models
Endothelial Cells
Blood Pressure

Keywords

  • atrial natriuretic factor infusion
  • endothelin infusion
  • endothelium
  • renal vasoconstriction
  • systemic vasoconstriction

ASJC Scopus subject areas

  • Physiology

Cite this

Endothelin in thoracic inferior vena caval constriction model of heart failure. / Underwood, R. D.; Aarhus, L. L.; Heublein, D. M.; Burnett, John C Jr.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 263, No. 3 32-3, 1992.

Research output: Contribution to journalArticle

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