Endothelin

A new cardiovascular regulatory peptide

Amir Lerman, F. L. Hildebrand, K. B. Margulies, B. O'Murchu, M. A. Perrella, D. M. Heublein, T. R. Schwab, John C Jr. Burnett

Research output: Contribution to journalArticle

146 Citations (Scopus)

Abstract

Endothelin, a recently discovered peptide produced by endothelial cells, contracts vascular strips in vitro with greater potency than any previously known vasoconstrictor. Infusions of pharmacologic doses of endothelin in vivo result in a prolonged pressor response and a preferential impairment of renal hemodynamic and excretory functions. Endothelin also directly stimulates the release of aldosterone from the adrenal gland and inhibits renin release in vitro. A highly sensitive and specific radioimmunoassay has confirmed that endothelin circulates in human plasma, and increased plasma endothelin levels have been associated with various cardiovascular disease states. This review summarizes the current knowledge about the molecular biologic features and physiologic actions of endothelin and also explores the role of endothelin, through its local and systemic function, as a regulator of vascular tone in normal and pathophysiologic states.

Original languageEnglish (US)
Pages (from-to)1441-1455
Number of pages15
JournalMayo Clinic Proceedings
Volume65
Issue number11
StatePublished - 1990

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Endothelins
Peptides
Vasoconstrictor Agents
Adrenal Glands
Aldosterone
Renin
Radioimmunoassay
Blood Vessels
Cardiovascular Diseases
Endothelial Cells
Hemodynamics
Kidney

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Lerman, A., Hildebrand, F. L., Margulies, K. B., O'Murchu, B., Perrella, M. A., Heublein, D. M., ... Burnett, J. C. J. (1990). Endothelin: A new cardiovascular regulatory peptide. Mayo Clinic Proceedings, 65(11), 1441-1455.

Endothelin : A new cardiovascular regulatory peptide. / Lerman, Amir; Hildebrand, F. L.; Margulies, K. B.; O'Murchu, B.; Perrella, M. A.; Heublein, D. M.; Schwab, T. R.; Burnett, John C Jr.

In: Mayo Clinic Proceedings, Vol. 65, No. 11, 1990, p. 1441-1455.

Research output: Contribution to journalArticle

Lerman, A, Hildebrand, FL, Margulies, KB, O'Murchu, B, Perrella, MA, Heublein, DM, Schwab, TR & Burnett, JCJ 1990, 'Endothelin: A new cardiovascular regulatory peptide', Mayo Clinic Proceedings, vol. 65, no. 11, pp. 1441-1455.
Lerman A, Hildebrand FL, Margulies KB, O'Murchu B, Perrella MA, Heublein DM et al. Endothelin: A new cardiovascular regulatory peptide. Mayo Clinic Proceedings. 1990;65(11):1441-1455.
Lerman, Amir ; Hildebrand, F. L. ; Margulies, K. B. ; O'Murchu, B. ; Perrella, M. A. ; Heublein, D. M. ; Schwab, T. R. ; Burnett, John C Jr. / Endothelin : A new cardiovascular regulatory peptide. In: Mayo Clinic Proceedings. 1990 ; Vol. 65, No. 11. pp. 1441-1455.
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