Endothelialization of cardiovascular devices

Research output: Contribution to journalReview article

Abstract

Blood-contacting surfaces of cardiovascular devices are not biocompatible for creating an endothelial layer on them. Numerous research studies have mainly sought to modify these surfaces through physical, chemical and biological means to ease early endothelial cell (EC) adhesion, migration and proliferation, and eventually to build an endothelial layer on the surfaces. The first priority for surface modification is inhibition of protein adsorption that leads to inhibition of platelet adhesion to the device surfaces, which may favor EC adhesion. Surface modification through surface texturing, if applicable, can bring some hopeful outcomes in this regard. Surface modifications through chemical and/or biological means may play a significant role in easy endothelialization of cardiovascular devices and inhibit smooth muscle cell proliferation. Cellular engineering of cells relevant to endothelialization can boost the positive outcomes obtained through surface engineering. This review briefly summarizes recent developments and research in early endothelialization of cardiovascular devices. Statement of Significance: Endothelialization of cardiovascular implants, including heart valves, vascular stents and vascular grafts is crucial to solve many problems in our health care system. Numerous research efforts have been made to improve endothelialization on the surfaces of cardiovascular implants, mainly through surface modifications in three ways – physically, chemically and biologically. This review is intended to highlight comprehensive research studies to date on surface modifications aiming for early endothelialization on the blood-contacting surfaces of cardiovascular implants. It also discusses future perspectives to help guide endothelialization strategies and inspire further innovations.

Original languageEnglish (US)
Pages (from-to)53-71
Number of pages19
JournalActa Biomaterialia
Volume99
DOIs
StatePublished - Nov 2019

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Equipment and Supplies
Surface treatment
Research
Cell Adhesion
Blood Vessels
Endothelial Cells
Cell Proliferation
Cell Engineering
Heart Valves
Cell adhesion
Endothelial cells
Adsorption
Smooth Muscle Myocytes
Cell Movement
Stents
Blood
Blood Platelets
Delivery of Health Care
Transplants
Texturing

Keywords

  • Cardiovascular
  • Endothelialization
  • Heart valve
  • Vascular graft
  • Vascular stent

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering
  • Molecular Biology

Cite this

Endothelialization of cardiovascular devices. / Jana, Soumen.

In: Acta Biomaterialia, Vol. 99, 11.2019, p. 53-71.

Research output: Contribution to journalReview article

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